Analysis of sequence variability of prion protein gene (PRNP) in Portuguese cervid populations species: red deer, fallow deer and roe deer

• Author(s): Pereira, Jorge C. ; Machado, Ana ; Gonçalves-Anjo, Nuno ; Bastos, Estela ; Orge, Leonor ; Rocha, Sara ; Figueira, Luís ; Matos, Ana Cristina ; Silva, João ; Mendonça, Paula ; Carvalho, Paulo ; Tavares, Paula ; Lima, Carla ; Alves, Anabela ; Esteves, Alexandra ; Pinto, Maria de Lurdes ; Pires, Isabel ; Gama, Adelina ; Sargo, Roberto ; Silva, Filipe ; Seixas, Fernanda ; Pinto, Madalena Vieira ; Pires, Maria dos Anjos
• Date: 2022
• Persistent ID: http://hdl.handle.net/10400.11/8767
• Origin: Repositório Científico do Instituto Politécnico de Castelo Branco
• Subject(s): Prion protein gene; Red deer; Fallow deer; Roe deer
• Document Type: Conference object
• Language: English
• Contributor(s): Repositório Científico do Instituto Politécnico de Castelo Branco

Description

Transmissible Spongiform Encephalopathy (TSE) or prion diseases are a family of neurodegenerative diseases caused by lethal infectious pathogens called Prions. Among the transmissible spongiform encephalopathies (TSEs), chronic wasting disease (CWD) in cervids is now the rising concern in wildlife within Europe, after the first case was detected in Norway in 2016, in a wild reindeer and until October 2021, a total of 40 cases were described in Norway, Sweden and Finland. The study of the genetics of the prion protein gene, PRNP, has been proved to be a valuable tool for determining the relative susceptibility to TSEs.