Poly(D,L-lactic acid) scaffolds as an innovative approach to the treatment of mixed S. aureus-C. albicans biofilms

• Author(s): Zegre, Miguel ; Barros, J. ; Ribeiro, I. A. ; Santos, C. ; Aranha Caetano, Liliana ; Gonçalves, L. ; Monteiro, F. ; Ferraz, M. ; Bettencourt, A.
• Date: 2023
• Persistent ID: http://hdl.handle.net/10400.21/16735
• Origin: Repositório Científico do Instituto Politécnico de Lisboa
• Subject(s): Bone infection; Minocycline; Voriconazole
• Document Type: Conference object
• Language: English
• Contributor(s): RCIPL

Description

Problem - Bone infections associated with polymicrobial biofilm formation; mixed bacterial-fungal biofilm infection; Staphylococcus aureus and Candida albicans most described microbials. Strategy - Local drug delivery scaffolds; development of poly-DL-lactic acid (PDLLA) scaffolds; co-delivery of antibacterial and antifungal drugs; minocycline and voriconazole as model drugs.