Autor(es): Fernandes, Nádia ; Araújo, Marta ; Lança, Carla ; Carvalho, Tiago
Data: 2023
Identificador Persistente: http://hdl.handle.net/10400.21/21321
Origem: Repositório Científico do Instituto Politécnico de Lisboa
Assunto(s): Ophthalmology; Age-related macular degeneration; Vitamin D; Vitamin supplementation; Choroidal imaging biomarkers; Retinal imaging biomarkers
Age-related Macular Degeneration (AMD) is a chronic and multifactorial aging retinal disease that causes irreversible central vision loss. In Europe, AMD represents the main cause of severe visual impairment and blindness in the elderly. Health status, low antioxidant diet, and sedentary lifestyles are modifiable risk factors. Health promotion and preventive medicine are essential to reduce the risk of disease progression and visual impairment. Vitamin D [25(OH)D] (Vit D) deficiency may be a risk factor for AMD. The anti-inflammatory potential of Vit D in AMD and its contribution to improving retinal antioxidant protection has been investigated. A systematic review and meta-analysis conducted by Ferreira et al. showed there was a trend for advanced AMD in people with serum Vit D<50nmol/L. Thus, increasing 25(OH)D levels through dietary intake and supplementation may be beneficial. A structural evaluation using SD-OCT and OCT-A seems to be an interesting tool for assessing changes in the retina and choroid after supplementation.
