Autor(es): Gamelas, Sara R. D. ; Bartolomeu, Maria ; Vieira, Cátia ; Faustino, Maria A. F. ; Tomé, João P. C. ; Tomé, Augusto C. ; Almeida, Adelaide ; Lourenço, Leandro M. O.
Data: 2023
Identificador Persistente: http://hdl.handle.net/10400.14/46474
Origem: Veritati - Repositório Institucional da Universidade Católica Portuguesa
Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photosensitizers (PS) in PDI has already proven effectiveness against various microorganisms [4]. Moreover, the addition of KI as a coadjutant can, in certain circumstances, enhance the efficiency of neutral, negative, and positively charged PS against Gram-negative and Gram-positive bacteria [2,4]. In this study will be demonstrated the effect of KI in PDI of E. coli and S. aureus with cationic Pcs bearing tris(trimethylammoniummethyl) or pyridinium-pyrazolyl groups.
