An Assessment of the Genetic Diversity of Leishmania infantum Isolates from Infected Dogs in Brazil

• Author(s): Batista, Luís Fábio da Silva ; Segatto, Marcela ; Guedes, Carlos Eduardo S. ; Sousa, Rosana Santos ; Rodrigues, Cleusa Alves Theodoro ; Brazuna, Júlia Cristina Maksoud ; Silva, Joselli Santos ; Santos, Silvana Ornelas ; Larangeira, Daniela Farias ; Macedo, Andréa Mara ; Schriefer, Nicolaus Albert Borges ; Veras, Patrícia Sampaio Tavares ; Batista, Luís Fábio da Silva ; Segatto, Marcela ; Guedes, Carlos Eduardo S. ; Sousa, Rosana Santos ; Rodrigues, Cleusa Alves Theodoro ; Brazuna, Júlia Cristina Maksoud ; Silva, Joselli Santos ; Santos, Silvana Ornelas ; Larangeira, Daniela Farias ; Macedo, Andréa Mara ; Schriefer, Nicolaus Albert Borges ; Veras, Patrícia Sampaio Tavares
• Date: 2014
• Origin: Oasisbr
• Document Type: Journal article
• Language: English

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Texto completo: acesso restrito. p. 799-806

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Correlations between the genetic diversity of Leishmania infantum (syn. L. chagasi) isolates and their respective geographic origins support the theoretic assumption that visceral leishmaniasis probably originated in the Old World. Because dogs are widely considered to be the main reservoir of this disease, the present study aimed to investigate the degree of genetic divergence among 44 leishmanial canine isolates from two Brazilian cities, Jequié and Campo Grande, located approximately 2,028 km from each other. We hypothesized that a low degree of genetic divergence would be observed among these isolates. In fact, statistical analyses found no significant differences between the isolates using both random amplified polymorphic DNA and multilocus microsatellite typing genotyping techniques with three and seven markers, respectively. These findings provide support for the recent introduction of L. infantum into the New World.