p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta 1-induced apoptosis of HuH-7 cells

• Autor(es): Fan, G ; Ma, X ; Wong, PY ; Rodrigues, CMP ; Steer, CJ
• Data: 2004
• Identificador Persistente: http://hdl.handle.net/10451/21066
• Origem: Repositório da Universidade de Lisboa
• Assunto(s): Biochemistry & Molecular Biology; Cell Biology
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico de Acesso Aberto da ULisboa

Descrição

The p53 tumor suppressor gene product plays an important role in the regulation of apoptosis. Transforming growth factor beta1 (TGF-beta1)-induced apoptosis in hepatic cells is associated with reduced expression of the retinoblastoma protein (pRb) and sub