p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta 1-induced apoptosis of HuH-7 cells

• Author(s): Fan, G ; Ma, X ; Wong, PY ; Rodrigues, CMP ; Steer, CJ
• Date: 2004
• Persistent ID: http://hdl.handle.net/10451/21066
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Biochemistry & Molecular Biology; Cell Biology
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico de Acesso Aberto da ULisboa

Description

The p53 tumor suppressor gene product plays an important role in the regulation of apoptosis. Transforming growth factor beta1 (TGF-beta1)-induced apoptosis in hepatic cells is associated with reduced expression of the retinoblastoma protein (pRb) and sub