Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

• Autor(es): Clemente, A ; Domingos, A ; Grancho, AP ; Iley, J ; Moreira, R ; Neres, J ; Palma, N ; Santana, AB ; Valente, E
• Data: 2001
• Identificador Persistente: http://hdl.handle.net/10451/21168
• Origem: Repositório da Universidade de Lisboa
• Assunto(s): Chemistry, Medicinal; Chemistry, Organic
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico de Acesso Aberto da ULisboa

Descrição

A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones. 3, with different substituent patterns at the beta -lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme, (C) 2001 Elsevier Science Ltd. All rights reserved.