Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

• Author(s): Clemente, A ; Domingos, A ; Grancho, AP ; Iley, J ; Moreira, R ; Neres, J ; Palma, N ; Santana, AB ; Valente, E
• Date: 2001
• Persistent ID: http://hdl.handle.net/10451/21168
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Chemistry, Medicinal; Chemistry, Organic
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico de Acesso Aberto da ULisboa

Description

A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones. 3, with different substituent patterns at the beta -lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme, (C) 2001 Elsevier Science Ltd. All rights reserved.