In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles : a potential approach for chronic diseases treatment

• Autor(es): Fonseca-Gomes, João ; Loureiro, Joana A ; Tanqueiro, Sara ; Mouro, Francisco ; Ruivo, Pedro ; Carvalho, Tânia ; Sebastião, Ana M ; Diógenes, Maria José ; Pereira, Maria Carmo
• Data: 2020
• Identificador Persistente: http://hdl.handle.net/10451/47280
• Origem: Repositório da Universidade de Lisboa
• Assunto(s): PLGA nanoparticles; Drug delivery systems; Liposomes; Long-lasting treatment; Nanocarriers; Solid lipid nanoparticles
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico de Acesso Aberto da ULisboa

Descrição

Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected.