Author(s): Mobasheri, Ali ; Fonseca, João Eurico ; Gualillo, Oreste ; Henrotin, Yves ; Largo, Raquel ; Herrero-Beaumont, Gabriel ; Rocha, Francisco Airton Castro
Date: 2021
Persistent ID: http://hdl.handle.net/10451/49559
Origin: Repositório da Universidade de Lisboa
Subject(s): Osteoarthritis; Biomarkers; Cartilage; Synovium; Inflammation
Osteoarthritis (OA) is the most common form of arthritis affecting more than 500 million people globally. It accounts for more pain and functional disability than any other musculoskeletal disease and is an important source of high societal and economic costs. Although the pathophysiology of OA is poorly understood, the risk factors associated with disease development are well-established. They include age, obesity, sex, previous incidence of joint injuries, meniscal damage, joint instability, malalignment, genetics, bone shape (including anatomical deformities), muscle weakness and sarcopenia, and metabolic disease. Although OA can affect any synovial joint, including joints in the hand, according to studies on the global burden of disease in 2010 and 2017, knee OA represents the greatest societal burden.
