Autor(es): Pereira, Margarida ; Cosme Silva, Filipa ; Simões, Sandra ; Ribeiro, Helena ; Almeida, António José ; Marto, Joana
Data: 2022
Identificador Persistente: http://hdl.handle.net/10451/58940
Origem: Repositório da Universidade de Lisboa
Assunto(s): Pediatric vehicle; Hydrogel; Swallowability; Palatability; Oral administration
Palatability and swallowability in the pediatric population are perceived as true challenges in the oral administration of medication. Pediatric patients have high sensitivity to taste and reduced ability to take solid dosage forms, which can often lead to a poor therapeutic compliance. It is crucial to find new strategies to simplify the oral administration of drugs to children. The present paper reports the development of a new hydrogel vehicle adapted to the pediatric population. Several polymers with similar properties were selected and adjustments were made to obtain the desired characteristics of the final product. The developed formulations were studied for organoleptic properties, rheology, mucoadhesion properties, preservative efficacy, and stability. Physical and chemical compatibilities between the vehicle and several drugs/medicines, at the time of administration, were also studied. Six final formulations with different polymers, odor, and color were chosen, and no known interactions with medications were observed. The proposed new oral vehicles are the first sugar-free vehicle hydrogels designed to make the intake of oral solid forms a more pleasant and safer experience for pediatric patients.
