Author(s): Nunes-Carneiro, Diogo ; Madanelo, Mariana ; Silva, Filipa ; Pestana, Nicole ; Ribeiro, Catarina ; Gil‐Sousa, Diogo ; Martins, La Salete ; Almeida, Manuela ; Dias, Leonidio ; J, Malheiro ; Cavadas, Vítor ; Castro‐Henriques, Antonio ; Fraga, Avelino ; Silva-Ramos, Miguel
Date: 2020
Persistent ID: http://hdl.handle.net/10400.16/2725
Origin: Repositório Científico da Unidade Local de Saúde de Santo António (ULSSA)
Subject(s): kidney volume; living donor; nephrectomy; transplantation
The donors' estimated glomerular filtration rate (eGFR) after living nephrectomy has been a concern, particularly in donors with smaller kindeys. Therefore, we developed this retrospective observational study in 195 donors to determine the ability remaining kidney volume indexed to weight (RKV/W) to predict eGFR at 1 year through multivariate linear regression and to explore this relationship between annual eGFR change from 1 to 4 years postdonation evaluated by a linear mixed model. Comparing RKV/W tertiles (T1, T2, T3), RKV/W was a good predictor of 1-year eGFR which was significantly better in T3 donors. Gender, predonation eGFR, and RKV/W were independent predictors of eGFR at 1-year. In a subgroup with predonation eGFR < 90mL/min/1.73 m2 , a significant prediction of eGFR < 60mL/min/1.73 m2 was detected in males with RKV/W ≤ 2.51cm3 /kg. Annual eGFR (ml/min/year) change from 1 to 4 years was + 0.77. RKV/W divided by tertiles (T1-T3) was the only significant predictor: T2 and T3 donors had an annual eGFR improvement opposing to T1. RKV/W was a good predictor of eGFR at 1 year, independently from predonation eGFR. A higher RKV/W was associated with improved eGFR at 1 year. A decline in eGFR on the four years after surgery was only noticeable in donors with RKV/W ≤ 2.13cm3 /kg.
