Autor(es): Plutín, Ana M. ; Alvarez, Anislay ; Mocelo, Raúl ; Ramos, Raúl ; Castellano, Eduardo E. ; da Silva, Monize M. ; Villarreal, Wilmer ; Pavan, Fernando R. [UNESP] ; Meira, Cássio Santana ; Filho, José Simão Rodrigues ; Moreira, Diogo Rodrigo M. ; Soares, Milena Botelho P. ; Batista, Alzir A.
Data: 2018
Identificador Persistente: http://hdl.handle.net/11449/178874
Origem: Oasisbr
Assunto(s): Metal complexes; Palladium; Thioureas; Trypanosoma cruzi; Tuberculosis
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibuthyl-N′-benzoylthioureato-k2O,S)]PF6, (4) [Pd(dppf)(N,N-diphenyl-N′-benzoylthioureato-k2O,S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N′-furoylthioureato-k2O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N′-furoylthioureato-k2O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N′- thiophenylthioureato-k2O,S)]PF6, and (8) [Pd(dppf)(N,N-diphenyl-N′-thiophenylthioureato-k2O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases.
Laboratorio de Síntesis Orgánica Facultad de Química Universidad de La Habana
Instituto de Física de São Carlos Universidade de São Paulo
Departamento de Química Universidade Federal de São Carlos
Faculdade de Ciências Farmacêuticas UNESP
Instituto Gonçalo Moniz Fundação Oswaldo Cruz
Centro de Biotecnologia e Terapia Celular Hospital São Rafael
Faculdade de Ciências Farmacêuticas UNESP
