Author(s): Tarallo, M. Belen ; Urquiola, Carolina ; Monge, Antonio ; Pavan, Fernando R. [UNESP] ; Leite, Clarice Q. [UNESP] ; Torre, Maria H. ; Gambino, Dinorah ; Collery, P. ; Maymard, I ; Theophanides, T. ; Khassanova, L. ; Collery, T.
Date: 2020
Persistent ID: http://hdl.handle.net/11449/197384
Origin: Oasisbr
Subject(s): M. tuberculosis; quinoxaline N-1,N-4-dioxides; iron complexes
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Three new iron complexes with 3-aminoquinoxaline-2-carbonitrile N-1, N-4-dioxide derivatives (L) with stoichiometries [Fe(L1)(2)], [Fe(L1)(3)] and [Fe(L2)(3)]center dot 5H(2)O were synthesized and characterized. Both ligands and complexes showed in vitro activity against Mycobacterium. tuberculosis H(37)Rv (ATCC 27294) (MIC=3.9 mu g/mL for [Fe(L1)(2)] and [Fe(L2)(3)]center dot 5H(2)O and 7.8 mu g/mL for [Fe(L1)(3)]) with low citotoxicity. Two of the three complexes presented better activity than the free ligands, demonstrating that metal coordination can favorably modify the profile of antimycobacterial activity of 3-aminoquinoxaline-2-carbonitrile N-1,N-4-dioxide derivatives.
Univ Republica, Fac Quim, Catedra Quim Inorgan, Gral Flores 2124,CC 1157, Montevideo 11800, Uruguay
Univ Navarra, CIFA, Pamplona, Spain
Unesp, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
Unesp, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
