Autor(es): Ramalho, Suelem D. [UNESP] ; Pinto, Meri Emili F. [UNESP] ; Andricopulo, Renata K. ; Sanches, Paulo R. S. [UNESP] ; Silveira, Edilberto R. ; Cilli, Eduardo M. [UNESP] ; Andricopulo, Adriano D. ; Bolzani, Vanderlan S. [UNESP]
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/201421
Origem: Oasisbr
Assunto(s): Fibroblast migration; Jatropha; Linear analogues; Orbitides
Made available in DSpace on 2020-12-12T02:32:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01. Added 1 bitstream(s) on 2021-07-15T15:07:38Z : No. of bitstreams: 1 S0103-50532019001002153.pdf: 2794919 bytes, checksum: cd2b9335294d2b610a9abbd5dc742734 (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Orbitides are a class of small naturally occurring cyclic peptides with structural and functional diversities. Their chemical properties make this class feasible to be obtained by solid phase peptide synthesis (SPPS). Therefore, this synthetic accessibility enables useful application and facilitates the identification of analogues, bioactivity studies, and thus, enables them to be applied to obtain peptide libraries. The aim of this work was to investigate the effects of orbitides and their linear synthetic analogues on the migration of neonatal human foreskin fibroblasts. The screening of linear peptide analogues, originally designed from natural orbitides isolated from Jatropha species, demonstrated that some molecules (linear pohlianin B and linear ribifolin) have the potential to induce fibroblast migration and collagen deposition and may thus contribute to accelerating the processes of wound healing and tissue repair. These results also demonstrate the significance of using peptides as an important tool for the discovery of simple and novel drug scaffolds.
Instituto de Química Universidade Estadual Paulista (Unesp)
Instituto de Física de São Carlos (IFSC) Universidade de São Paulo (USP)
Departamento de Fisiologia e Farmacologia Universidade Federal do Ceará (UFC)
Instituto de Química Universidade Estadual Paulista (Unesp)
FAPESP: 2015/09533-7
