Author(s): Sonon, Paulin ; Collares, Cristhianna V.A. ; Ferreira, Maria Lúcia Brito ; Almeida, Renata Santos ; Sadissou, Ibrahim ; Cordeiro, Marli Tenório ; de Fátima Militão de Albuquerque, Maria ; Castelli, Erick C. [UNESP] ; Lucena-Silva, Norma ; Donadi, Eduardo A.
Date: 2021
Persistent ID: http://hdl.handle.net/11449/207658
Origin: Oasisbr
Subject(s): Arbovirus; ESD; HLA-E; HLA-F; Pernambuco; PSD
Made available in DSpace on 2021-06-25T10:58:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-01
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação Oswaldo Cruz
Introduction: Non-classical class I human leukocyte antigens (HLA) molecules are known to modulate the function of cytotoxic cells (NK and T CD8+) during viral infection by interacting with inhibitory/activating receptors. However, little is known about the HLA-E/-F genetic variability on arbovirus infections. Methods: We evaluated by massive parallel sequencing the full HLA-E/-F genetic diversity among patients infected during the arbovirus (ZIKV, DENV, and CHIKV) outbreak leading to a broad range of neurological complications in the Brazilian State of Pernambuco. In parallel, healthy blood donors from the same area were also studied. Plink and R software were used for genetic association study. To limit the false-positive results and enhance the reliability of the results, we adopted P-values <0.01 as significant levels. Results: Compared to controls, the HLA-F alleles: −1610 C (rs17875375), +1383 G (rs17178385), and +3537 A (rs17875384), all in complete linkage disequilibrium with each other (r2 = 1), were overrepresented in patients presenting peripheral spectrum disorders (PSD). The HLA-F*Distal-D haplotype that harbored the −1610 C allele exhibited a trend increase in PSD group. No associations were found for HLA-E. Conclusions: Our findings showed that the HLA-F genetic background seems to be more important than HLA-E on the susceptibility to PSD complications.
Immunogenetic Laboratory Immunology Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
Ribeirão Preto Medical School University of São Paulo, AV Bandeirantes, 3900, HC, Vila Monte Alegre
Hospital da Restauração Gov. Paulo Guerra, Av. Gov. Agamenon Magalhães, s/n, Derby
Virology Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
Public Health Department Aggeu Magalhães Institute Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
São Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory Prof. Dr. Walter Maurício Correa, s/n Unesp, Campus de Botucatu
São Paulo State University (UNESP) Department of Pathology School of Medicine
São Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory Prof. Dr. Walter Maurício Correa, s/n Unesp, Campus de Botucatu
São Paulo State University (UNESP) Department of Pathology School of Medicine
CNPq: 302060/2019-7
CNPq: 310364/2015-9
CNPq: 310892/2019-8
CNPq: 440760/2016-0
CAPES: 88881.130769/2016-01
Fundação Oswaldo Cruz: INOVA FIOCRUZ/02/2019 PDJ
