Author(s): Pereira, Ticiana Praciano ; Campos, Adriana Rolim ; Leal, Luzia Kalyne A. M. ; Pierdoná, Taiana Magalhães ; Toyama, Marcos H. [UNESP] ; Monteiro, Helena Serra Azul ; Martins, Alice Maria Costa
Date: 2022
Persistent ID: http://hdl.handle.net/11449/226032
Origin: Oasisbr
Subject(s): Crotalus durissus cumanensis venom; Glibenclamide; Nociception
Made available in DSpace on 2022-04-28T21:24:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01
The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 μg/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinociceptive mechanism of CDCM.
Department of Pharmacy Federal University of Ceara, Fortaleza, Ceara
Vice-Rectory of Research and Post-Graduation Fortaleza University, Fortaleza, Ceara
Department of Physiology and Pharmacology Federal University of Ceara, Fortaleza, Ceara
São Vicente United Campus of Litoral Paulista Paulista State University, Sao Paulo, Sao Paulo
Department of Clinical and Toxicological Analyses Federal University of Ceara, Fortaleza, Ceara
São Vicente United Campus of Litoral Paulista Paulista State University, Sao Paulo, Sao Paulo
