Author(s): Katayama, Pedro L. [UNESP] ; Leirão, Isabela P. [UNESP] ; Kanashiro, Alexandre ; Luiz, João P.M. ; Cunha, Fernando Q. ; Navegantes, Luiz C.C. ; Menani, Jose V. [UNESP] ; Zoccal, Daniel B. [UNESP] ; Colombari, Débora S.A. [UNESP] ; Colombari, Eduardo [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/231640
Origin: Oasisbr
Subject(s): Carotid body; Inflammation; Neural circuits; Neuroimmune interactions; Neuroimmunomodulation; Sympathetic nervous system
Made available in DSpace on 2022-04-29T08:46:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-05-01
Booz Allen Foundation
Recent evidence has suggested that the carotid bodies might act as immunological sensors, detecting pro-inflammatory mediators and signalling to the central nervous system, which, in turn, orchestrates autonomic responses. Here, we confirmed that the TNF-α receptor type I is expressed in the carotid bodies of rats. The systemic administration of TNF-α increased carotid body afferent discharge and activated glutamatergic neurons in the nucleus tractus solitarius (NTS) that project to the rostral ventrolateral medulla (RVLM), where many pre-sympathetic neurons reside. The activation of these neurons was accompanied by an increase in splanchnic sympathetic nerve activity. Carotid body ablation blunted the TNF-α-induced activation of RVLM-projecting NTS neurons and the increase in splanchnic sympathetic nerve activity. Finally, plasma and spleen levels of cytokines after TNF-α administration were higher in rats subjected to either carotid body ablation or splanchnic sympathetic denervation. Collectively, our findings indicate that the carotid body detects circulating TNF-α to activate a counteracting sympathetic anti-inflammatory mechanism.
Department of Physiology and Pathology School of Dentistry São Paulo State University, São Paulo
Department of Neurosciences and Behavior Ribeirão Preto Medical School University of São Paulo, São Paulo
Department of Pharmacology Ribeirão Preto Medical School University of São Paulo, São Paulo
Department of Physiology Ribeirão Preto Medical School University of São Paulo, São Paulo
Department of Physiology and Pathology School of Dentistry São Paulo State University, São Paulo
Booz Allen Foundation: 2015/23467-7
Booz Allen Foundation: 2019/11196-0
Booz Allen Foundation: PROPE-UNESP
