Peptide-induced permeation of model membranes by antimicrobial peptidomimetics

• Author(s): Carvalho, Carina Martins ; Castro, Vânia I. B. ; Pereira-Lima, Sílvia M. M. A. ; Costa, Susana P. G. ; Castanheira, Elisabete M. S.
• Date: 2015
• Persistent ID: http://hdl.handle.net/1822/37844
• Origin: RepositóriUM - Universidade do Minho
• Project/scholarship: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/118389/PT ; info:eu-repo/grantAgreement/FCT/COMPETE/132953/PT; info:eu-repo/grantAgreement/FCT/COMPETE/132974/PT; info:eu-repo/grantAgreement/FCT/COMPETE/118389/PT
• Subject(s): Antimicrobial peptides; Model membranes; Ciências Naturais::Ciências Químicas
• Document Type: Conference object
• Language: English
• Contributor(s): Universidade do Minho

Description

In the present communication, a set of Peptaibolin and several peptidomimetics incorporating unnatural α,α-dialkylglycines (Deg, Dpg, Ac6c) were studied for their ability to interact and permeate model membranes from phosphatidylcholine/cholesterol, in different ratios. The permeation activity was monitored by fluorescence spectroscopy, following the release of encapsulated 6-carboxyfluorescein.

Fundação para a Ciência e a Tecnologia (Portugal) and FEDER-COMPETE-QREN-EU for financial support through projects PTDC/QUI-BIQ/118389/2010 (FCOMP-01-0124-FEDER-020906), PEst-C/QUI/UI0686/2013 (F-COMP-01-0124-FEDER-037302), and PEst-C/FIS/UI0607/2013 (F-COMP-01-0124-FEDER-022711).