Author(s):
Costa, André Manuel Abreu ; Machado, Raul ; Ribeiro, Artur J. ; Collins, Tony ; Thiagarajan, V. ; Neves-Petersen, M.T. ; Rodríguez-Cabello, J.C. ; Gomes, Andreia C ; Casal, Margarida
Date: 2015
Persistent ID: https://hdl.handle.net/1822/46188
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/5876/135919/PT;
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F75882%2F2011/PT;
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F86470%2F2012/PT;
Subject(s): Ciências Médicas::Outras Ciências Médicas
Description
[Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. In the present work we explored the ABP-CM4 peptide properties from Bombyx mori for the creation of biopolymers with broad antimicrobial activity. An antimicrobial recombinant protein-based polymer (rPBP) was designed by cloning the DNA sequence coding for ABP-CM4 in frame with the N-terminus of the elastin-like recombinamer consisting of 200 repetitions of the pentamer VPAVG, here named A200. [...]
This work was supported by FEDER through POFC – COMPETE by FCT through the project PEst-OE/BIA/UI4050/2014. By the Spanish Minister of Economy and Competitiveness (MAT2012-38043-C02-01) and Junta de Castilla y León-JCyL (VA152A12-2 and VA155A12-2), Spain. AC and RM, acknowledge FCT for SFRH/BD/75882/2011 and SFRH-BPD/86470/2012 grants, respectively.