Author(s): Silva, Rui ; Aguiar, Tatiana Quinta ; Oliveira, Rui ; Domingues, Lucília
Date: 2017
Persistent ID: http://hdl.handle.net/1822/48498
Origin: RepositóriUM - Universidade do Minho
Project/scholarship: info:eu-repo/grantAgreement/FCT/5876/147337/PT; info:eu-repo/grantAgreement/FCT/5876-PPCDTI/126270/PT ; info:eu-repo/grantAgreement/FCT/COMPETE/126270/PT;
Microbiotec'17 - Congress of Microbiology and Biotechnology 2017
Background The overproduction of riboflavin by Ashbya gossypii, which is one of the most distinctive traits of this filamentous hemiascomycete, is triggered by oxidative stress [1]. In turn, riboflavin is a strong photosensitizer that upon irradiation with light has been shown to generate reactive oxygen species (ROS) and induce oxidative DNA damage in mammalian cells [2-3]. Envisioning a better understanding of this A. gossypii trait, here we investigated whether riboflavin overproduction is associated with increased DNA damage. [...]
Study supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) (Post-Doc grant to T. Q. Aguiar), BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte, Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124FEDER-027462) and PhD grant PD/BD/113812/2015 to R. Silva.
info:eu-repo/semantics/publishedVersion
