Author(s):
Carvalho, Carina Martins ; Castro, Vânia Isabel Baptista ; Pereira-Lima, Sílvia M. M. A. ; Castanheira, Elisabete M. S. ; Costa, Susana P. G.
Date: 2015
Persistent ID: http://hdl.handle.net/1822/49316
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/118389/PT
;
info:eu-repo/grantAgreement/FCT/COMPETE/132953/PT;
Subject(s): Unnatural amino acids; Peptide mimetics; Fluorescence spectroscopy; Model membranes; Ciências Naturais::Ciências Químicas
Description
Comunicação em painel P60 no 2nd Symposium on Medicinal Chemistry, Braga, Portugal, 8 Maio 2015
It is reported the membrane permeation studies of Peptaibolin and several mimetics incorporating unnatural α,α-dialkylglycines (Deg, Dpg, Ac6c) with model membranes (egg phosphatidylcholine/cholesterol, in different ratios). The permeation activity was monitored by fluorescence spectroscopy, following release of an encapsulated fluorescent probe (6-carboxyfluorescein). The obtained results revealed a correlation between the length and bulk of the side chain of the unnatural α,α-dialkylglycines and the ability of the corresponding peptide to permeate the model membranes.
Fundação para a Ciência e Tecnologia(Portugal) and FEDER-COMPETE for financial support through project PTDC/QUI-BIQ/118389/2010 (FCOMP- 01-0124-FEDER-020906) and PEst-C/QUI/UI0686/2013 (F-COMP-01-0124-FEDER-037302). The NMR spectrometer Bruker Avance III 400 is part of the National NMR Network and was purchased with fund s from FCT and FEDER
info:eu-repo/semantics/publishedVersion
