Author(s):
Carvalho, Agostinho ; Pasqualotto, A. C. ; Pitzurra, L. ; Romani, L ; Denning, D. W. ; Rodrigues, Fernando José dos Santos
Date: 2008
Persistent ID: http://hdl.handle.net/1822/61456
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/POCI/61080/PT
;
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F11837%2F2003/PT;
Subject(s): Aged; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Aspergillus fumigatus; Case-Control Studies; Cohort Studies; Female; Humans; Lung Diseases, Fungal; Male; Middle Aged; Polymorphism, Single Nucleotide; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptor 9; Science & Technology
Description
Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.
Fundação para a Ciência e Tecnologia, Portugal (POCI/SAU-ESP/61080/ 2004 and fellowship to A.C., contract SFRH/BD/11837/2003); CAPES (Brazilian government) (grant to A.P); and the Fungal Research Trust, United Kingdom.
