Author(s):
Carvalho, Agostinho ; Santos, M. ; Maciel, P. ; Rodrigues, Fernando José dos Santos
Date: 2008
Persistent ID: http://hdl.handle.net/1822/61457
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F11837%2F2003/PT;
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F9111%2F2002/PT;
info:eu-repo/grantAgreement/FCT/POCI/61080/PT
;
Subject(s): Adult; Age of Onset; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Multiple Sclerosis; Portugal; Promoter Regions, Genetic; Severity of Illness Index; Toll-Like Receptor 9; Polymorphism, Genetic; Disease; Inflammation; Innate immunity; Susceptibility; toll-like receptor; Science & Technology
Description
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, with disturbances of the immunological balance. As TLR9-null mice showed increased resistance to experimental autoimmune encephalomyelitis and recent genetic investigations showed that T-1237C promoter polymorphism of TLR9, commonly implicated in autoimmune diseases, induces a deregulation of its expression, we performed an association study in a Portuguese population of 165 MS patients and unrelated healthy controls. Our results show no significant association with MS and no protective effect of T-1237C concerning age of onset, disease severity or disease subtype in MS patients.
Carvalho A (grant SFRH/BD/11837/2003) and Santos M (grant SFRH/BD/9111/2002) were financially supported by Fundação para a Ciência e Tecnologia, Portugal. This study was supported by Fundação para a Ciência e Tecnologia, Portugal (POCI/SAU-ESP/61080/2004).
