The neurobiological hypothesis of neurotrophins in the pathophysiology of schizophrenia: A meta-analysis

• Author(s): Rodrigues-Amorim, Daniela ; Rivera-Baltanás, Tania ; Peixoto, João Miguel Seiça Bessa ; Sousa, Nuno ; Vallejo-Curto, María de Carmen ; Rodríguez-Jamardo, Cynthia ; de Las Heras, María Elena ; Díaz, Roberto ; Agís-Balboa, Roberto Carlos ; Olivares, J. M. ; Spuch, Carlos
• Date: 2018
• Persistent ID: https://hdl.handle.net/1822/57939
• Origin: RepositóriUM - Universidade do Minho
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

Schizophrenia is associated with patterns of aberrant neurobiological circuitry. The disease complexity is mirrored by multiple biological interactions known to contribute to the disease pathology. One potential contributor is the family of neurotrophins which are proteins involved in multiple functional processes in the nervous system, with crucial roles in neurodevelopment, synaptogenesis and neuroplasticity. With these roles in mind, abnormal neurotrophin profiles have been hypothesized to contribute to the pathology of schizophrenia.