Concept of extremes in vascular aging: from early vascular aging to supernormal vascular aging

• Author(s): Laurent, Stephane ; Boutouyrie, Pierre ; Cunha, Pedro Miguel Guimarães Marques ; Lacolley, Patrick ; Nilsson, Peter M.
• Date: 2019
• Persistent ID: https://hdl.handle.net/1822/62405
• Origin: RepositóriUM - Universidade do Minho
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

[Excerpt] With advancing age, changes in the arterial wall contribute to what has been called vascular aging, and in some prematurely affected subjects even early vascular aging (EVA).1–5 Several years ago,1 we listed various components of EVA, including arteriosclerosis, atherosclerosis, and excess vasoconstriction, with their clinical expression: arterial stiffening and increased central pulse pressure, carotid intima media thickening and endothelial dysfunction, and increased total peripheral resistance, respectively.[...]