Autor(es): Brito, Alexandra ; Pereira, Patrícia M. ; Costa, Diana Soares da ; Reis, R. L. ; Ulijn, Rein V. ; Lewis, Rein V. ; Pires, R. A. ; Pashkuleva, I.
Data: 2020
Identificador Persistente: https://hdl.handle.net/1822/66345
Origem: RepositóriUM - Universidade do Minho
Assunto(s): Apoptosis; Biocatalytic self-assembly; GLUT inhibitor; Osteosarcoma; Warburg effect
We report on aromatic N-glucosides that inhibit selectively the cancer metabolism via two coexistent mechanisms: by initial deprivation of the glucose uptake through competitive binding in the glucose binding pocket of GLUT1 and by formation of a sequestering nanoscale supramolecular network at the cell surface through localized (biocatalytic) self-assembly. We demonstrate that the expression of the cancer associated GLUT1 and alkaline phosphatase are crucial for the effectiveness of this combined approach: cancer cells that overexpress both proteins are prompter to cell death when compared to GLUT1 overexpressing cells. Overall, we showcase that the synergism between physical and biochemical deprivation of cancer metabolism is a powerful approach for development of effective anticancer therapies.
