Autor(es): da Silva, Lucília Pereira ; Kundu, Subhas C ; Reis, R. L. ; Correlo, V. M.
Data: 2020
Identificador Persistente: https://hdl.handle.net/1822/91874
Origem: RepositóriUM - Universidade do Minho
Assunto(s): Electrical stimulation; Tissue engineering; electrical current; electrical field; electroactive biomaterials
Tissue engineering and regenerative medicine (TERM) are paving the way to the generation of functional and mature biological tissues that closely emulate cellular, biochemical, and mechanical cues. Electrical fields in the human body modulate myriad biological processes, such as synapses, muscle contraction, hearing, and wound healing, which were disregarded in TERM until recently. To preserve and improve tissue electrophysiology, cells can be loaded in electroactive biomaterials and stimulated with exogenous electrical fields. Here, we review how electrical stimulation and electroactive biomaterials can be used to instruct cells to create more mature and functional tissue-engineered constructs. We also highlight the most recent electroactive engineered tissues developed for TERM.
