Autor(es): Alves, Cátia Sofia Pereira ; Melro, Liliana Sofia Silva Ferreira Pinto ; Fernandes, Marta Susana Machado ; Padrão, Jorge ; Moldes, Diego ; Serra, Sofia Cravino ; Salgado, A. J. ; Zille, Andrea
Data: 2025
Identificador Persistente: https://hdl.handle.net/1822/97501
Origem: RepositóriUM - Universidade do Minho
[Excerpt] This research envisages the use of bacterial nanocellulose (BNC) as a biomaterial for implants to mitigate neuralgias, focusing on the material's inherent limitations. BNC is widely valued for its excellent mechanical properties, ease of modification, and non-anthropogenic degradability [1]. However, its absent electrical conductivity, insufficient antimicrobial activity, and weak interaction with neural tissues restrict its application as a neural implant [2-4]. To overcome these challenges, lignin/glycerine was incorporated into BNC, and a dielectric barrier discharge (DBD) plasma surface treatment was applied to enhance biocompatibility and improve integration with neural tissues. Plasma treatment is known to modify surface characteristics, namely hydrophilicity and protein adsorption, facilitating cell adhesion and reducing immune response [5]. [...]
