Author(s): Sousa, Sara ; Pestana, Diogo ; Faria, Gil ; Delerue-Matos, Cristina ; Calhau, Conceição ; Fernandes Domingues, Valentina
Date: 2023
Persistent ID: http://hdl.handle.net/10362/158379
Origin: Repositório Institucional da UNL
Subject(s): Adipocytes; Biochemical parameters; Lipid; Metabolism; Obesity; Women; Clinical Biochemistry; Cell Biology; SDG 3 - Good Health and Well-being
Funding Information: S. Sousa is grateful to FCT and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). The authors thank the General Surgery Department of Hospital de São João (Porto, Portugal) and to all patients that consented to participate. Funding Information: This work was financially supported by Portuguese national funds through projects UIDB/50006/2020 , UIDP/50006/2020 , and LA/P/0008/2020 , from the Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência , Tecnologia e Ensino Superior . Funding Information: S. Sousa is grateful to Fundação para a Ciência e a Tecnologia and European Social Fund through Programa Operacional Capital Humano for the Ph.D . grant ( SFRH/BD/137516/2018-COVID/BD/153231/2023 ). Publisher Copyright: © 2023 Elsevier Ltd
Fatty acids (FA) are biomarkers of metabolic dysfunction. Adipose tissue is the largest reservoir of FA and acts differently in obese individuals. Menopause by itself significantly alters metabolism, lipid metabolism dysregulation, and adipose tissue distribution. How adipose tissue FA alters an obese individual's metabolism depending on a female's menopausal status is yet poorly understood. Hence, the subcutaneous (scAT) and visceral adipose tissue (vAT) FA profile for 173 obese premenopausal and postmenopausal women was measured and associated with biochemical parameters. scAT and vAT FA profiles were distinct by themselves and in menopause. In total 816 associations were found with biochemical parameters, where only 58 were independent of the menopausal status. The associations found to emphasize the importance of assessing the adipose tissue FA profile and how their behavior changes with menopause. The FA are crucial in metabolic processes and can be helpful biomarkers in the prevention/treatment and follow-up of female obesity.
