Autor(es):
Prasad, Rajendra ; Jain, Nishant K. ; Yadav, Amit S. ; Chauhan, Deepak S. ; Devrukhkar, Janhavi ; Kumawat, Mukesh K. ; Shinde, Shweta ; Gorain, Mahadeo ; Thakor, Avnesh S. ; Kundu, Gopal C. ; Conde, João ; Srivastava, Rohit
Data: 2020
Identificador Persistente: http://hdl.handle.net/10362/99540
Origem: Repositório Institucional da UNL
Assunto(s): Biochemistry, Genetics and Molecular Biology(all); Agricultural and Biological Sciences(all); Medicine (miscellaneous); SDG 3 - Good Health and Well-being
Descrição
Developing a nanotheranostic agent with better image resolution and high accumulation into solid tumor microenvironment is a challenging task. Herein, we established a light mediated phototriggered strategy for enhanced tumor accumulation of nanohybrids. A multifunctional liposome based nanotheranostics loaded with gold nanoparticles (AuNPs) and emissive graphene quantum dots (GQDs) were engineered named as NFGL. Further, doxorubicin hydrochloride was encapsulated in NFGL to exhibit phototriggered chemotherapy and functionalized with folic acid targeting ligands. Encapsulated agents showed imaging bimodality for in vivo tumor diagnosis due to their high contrast and emissive nature. Targeted NFGL nanohybrids demonstrated near infrared light (NIR, 750 nm) mediated tumor reduction because of generated heat and Reactive Oxygen Species (ROS). Moreover, NFGL nanohybrids exhibited remarkable ROS scavenging ability as compared to GQDs loaded liposomes validated by antitumor study. Hence, this approach and engineered system could open new direction for targeted imaging and cancer therapy.
