Author(s): Mayrink,Wilson ; Santos,Gilmara Cristina dos ; Toledo,Vicente de Paulo Coelho Peixoto de ; Guimarães,Tânia Mara Pinto Dabés ; Machado-Coelho,George Luis Lins ; Genaro,Odair ; Costa,Carlos Alberto da
Date: 2002
Origin: Oasisbr
Subject(s): Leishmania; Vaccine; Interferon-gamma; Interleukin-4
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
