Susceptibility to amphotericin B of Candida spp. strains isolated in Ceará, Northeastern Brazil

• Autor(es): Silva,Cecília Rocha da ; Magalhães,Hemerson Iury Ferreira ; Moraes,Manoel Odorico de ; Nobre Júnior,Hélio Vitoriano
• Data: 2013
• Origem: Oasisbr
• Assunto(s): Amphotericin B; Candida spp; Protocol M27-A3
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

IntroductionAmphotericin B (AMB) is an antifungal agent used extensively in clinical medicine, yet resistance remains low. This study aims to evaluate the susceptibility of Candida spp. against AMB.MethodsFor broth microdilution susceptibility testing, 77 strains of Candida spp. were selected (32 C. albicans, 33 C. tropicalis, and 12 C. parapsilosis). The strains were considered susceptible when they exhibited MIC≤1.0µg/ml.ResultsNone of the strains showed an MIC greater than 0.25µg/ml.ConclusionsFurther works are necessary, with a higher number of strains, to assess the validity of the results used in this study.