Author(s): Coelho,Inês ; Ferreira,Hugo ; Chuva,Teresa ; Paiva,Ana ; Maximino,José
Date: 2020
Origin: SciELO Portugal
Subject(s): Acute kidney injury; cast nephropathy; dialysis; multiple myeloma; serum free light chains
Document details
Extracorporeal light chains removal - What role does this play in 2020?
Description
Multiple Myeloma (MM) is characterized by a neoplastic proliferation of plasma cell clones producing monoclonal immunoglobulin. Manifestations of the disease are heterogenous and include dialysis-requiring acute kidney injury (AKI) caused mainly by cast nephropathy (CN). It is known that early and rapid decrease in serum free light chains (sFLC) levels is particularly important for renal recovery, which has led to a renewed interest in extracorporeal methods of removal of sFLC. In this review we will discuss the management of light chain CN focusing on extracorporeal light chains removal modalities and their indication.
Document Type
Journal article
Language English
Language English
