Author(s): Arruda Filho, Antônio Casella V. ; Rodrigues, P. A. S. ; Benjamin, Stephen Rathinaraj ; Paim, Raquel Teixeira Terceiro ; Holanda, M. O. ; Silva, J. Y. G. ; Milo, T. S. ; Vieira, I. G. P. ; Queiroz, Maria Goretti Rodrigues de ; Guedes, M. I. F.
Date: 2018
Origin: Oasisbr
Subject(s): Dislipidemias; Dyslipidemias
Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and triglycerides were significantly reduced plasma levels in PCO-C at the dose of 100 mg/kg in a model of acute and chronic dyslipidemia. Histological studies showed that PCO-C has no hepatotoxic effect and reduces hepatic steatosis in animals that consumed hyperlipidemic ration. Thus, it was concluded that PCO-C isolated from Copernicia Prunifera was effective in reducing total cholesterol and triglyceride levels in both dyslipidemia induction models. The finding indicates that PCO-C might be beneficial in treatment of hyperlipidemia and atherosclerosis.
