Author(s): Jardim, Guilherme A. M. ; Cruz, Eduardo H. G. da ; Valença, Wagner O. ; Lima, Daisy J. B. ; Cavalcanti, Bruno C. ; Pessoa, Claudia ; Rafique, Jamal ; Braga, Antonio L. ; Jacob, Claus ; Silva Júnior, Eufrânio N. da
Date: 2018
Origin: Oasisbr
Subject(s): Selênio; Selenium
Abstract: In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), NCIH-460 (human lung cells) and PC3 (human prostate cancer cells). Some compounds showed good activity with IC50 values below 1 M. The cytotoxic potential of the naphthoquinoidal derivatives was also evaluated in non-tumor cells, exemplified by L929 cells. Overall, these compounds represent promising new lead derivatives and stand for a new class of chalcogenium-containing derivatives with potential antitumor activity.
