GABAergic transmission and modulation of anxiety: a review on molecular aspects

• Autor(es): Gomes, Francisco Isaac Fernandes ; Aragão, Maria Gerusa Brito ; Bezerra, Mirna Marques ; Chaves, Hellíada Vasconcelos
• Data: 2019
• Origem: Oasisbr
• Assunto(s): Ansiedade; Anxiety; Pharmacotherapy; Farmacoterapia
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

Stress responses activate protective mechanisms to achieve homeostasis, but they can be detrimental when such responses become maladaptive. Anxiety relates to risk assessment of a potential threat and involves uncertainty regarding the anticipation of a threatening situation and it dampers quality of life. Gamma-Aminobutyric Acid (GABA) is the major inhibitory system in the central nervous system and plays a key role in the regulation of neuronal transmission in the brain, affecting many physiological and psychological processes. This mini-review aims to summarize key points concerned with the GABAergic transmission and basic aspects related to the GABAergic system in anxiety.