Author(s): Martins, Ana Caroline Vieira ; Lima Neto, Pedro de ; Barroso Neto, Ito Liberato ; Cavada, Benildo Sousa ; Freire, Valder Nogueira ; Caetano, Ewerton Wagner Santos
Date: 2020
Origin: Oasisbr
Subject(s): Central nervous system; Amino acids; Electrophysiological
We report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA . glutamate. kainate . DNQX, which explains published experimental data on GluR2 activation and antagonism strength.
