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New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synthesis and Characterization

Author(s): Teixeira, Fatima ; Lucas, Carla ; Curto, Maria João Marcelo ; Neves, M. ; Duarte, M. Teresa ; Andre, Vania ; Teixeira, António P. S.

Date: 2013

Persistent ID: http://hdl.handle.net/10400.9/2033

Origin: Repositório do LNEG

Subject(s): Bisphosphonates; Spectroscopic characterization; Synthesis; X-ray diffractometry; Bisphosphonates; Bisphosphonates; Spectroscopic characterization; Spectroscopic characterization; Synthesis; Synthesis; X-ray diffractometry; X-ray diffractometry

Description

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono- and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the proposed structure.

Document Type Journal article
Language English
Contributor(s) Repositório do LNEG

Document details

New 1-Hydroxy-1,1-bisphosphonates derived from 1H-Pyrazolo[3,4-b]pyridine: Synthesis and Characterization

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