Autor(es):
Ladeira, Carina ; Gomes, Manuel C. ; Brito, Miguel
Data: 2010
Identificador Persistente: http://hdl.handle.net/10400.21/678
Origem: Repositório Científico do Instituto Politécnico de Lisboa
Assunto(s): Anatomia patológica; Saúde ocupacional; Formaldeído; Tabagismo; Consumo de álcool; Factor de risco; Anatomia patológica; Anatomia patológica; Saúde ocupacional; Saúde ocupacional; Formaldeído; Formaldeído; Tabagismo; Tabagismo; Consumo de álcool; Consumo de álcool; Factor de risco; Factor de risco
Descrição
Formaldehyde is classified by IARC as carcinogenic to humans (nasopharyngeal cancer). Tobacco smoke has been epidemiologically associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco’s compounds. XRCC3 is involved in homologous recombination repair of cross-links and chromosomal double-strand breaks (Thr241Met polymorphism). The aim of the study is to determine whether there is an in vivo association between genetic polymorphism of the gene XRCC3 and the frequency of genotoxicity biomarkers in subjects exposed or not to formaldehyde and with or without tobacco consumption.
