Author(s): Simões, Maria de Fátima ; Rijo, Patrícia ; Duarte, Aida ; Barbosa, Diana ; Matias, Diogo ; Delgado, Joana ; Cirilo, Nádia ; Rodríguez, Benjamín
Date: 2010
Origin: Repositório da Universidade de Lisboa
Subject(s): Plectranthus saccatus; Plectranthus porcatus; Lamiaceae; Diterpenes; Beyerane; 13,16-Cycloabietane; Biological activity
Two new diterpenoids, ent-7α-acetoxy-15-beyeren-18-oic acid and (13S,15S)-6β,7α,12α,19-tetrahydroxy-13β,16-cyclo-8-abietene-11,14-dione, have been isolated from Plectranthus saccatus and Plectranthus porcatus, respectively, and their structures were established by 1D and 2D NMR spectroscopic studies. The new diterpenes showed no activity against Gram-negative bacteria and Candida albicans (yeast strain). Among Gram-positive bacteria, the lower MIC value was 62.50 μg/ml for the abietane derivative against Staphylococcus aureus ATCC 6538.
