Author(s):
Ferreira, Natália Noronha [UNESP] ; Caetano, Bruno Leonardo [UNESP] ; Boni, Fernanda Isadora [UNESP] ; Sousa, Flávia ; Magnani, Marina [UNESP] ; Sarmento, Bruno ; Ferreira Cury, Beatriz Stringhetti [UNESP] ; Daflon Gremião, Maria Palmira [UNESP]
Date: 2019
Persistent ID: http://hdl.handle.net/11449/187268
Origin: Oasisbr
Subject(s): alginate hydrogel; bevacizumab-alginate polyelectrolyte complexes; supramolecular interactions; sustained release; system microstructure; alginate hydrogel; alginate hydrogel; bevacizumab-alginate polyelectrolyte complexes; bevacizumab-alginate polyelectrolyte complexes; supramolecular interactions; supramolecular interactions; sustained release; sustained release; system microstructure; system microstructure
Description
Made available in DSpace on 2019-10-06T15:30:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-01
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundació Catalana de Trasplantament
European Regional Development Fund
Alginate-based polyelectrolyte complexes (PECs) and hydrogel were engineered as platforms for local bevacizumab (BVZ) therapy. This study provides deep comprehension on the microstructures of such systems, and their correlation with drug-release patterns. PECs and hydrogel were characterized using Fourier transform infrared spectroscopy, small-angle X-ray scattering, scanning electron microscopy, atomic force microscopy, and porosimetry. Structural investigations indicated that PECs are formed by supramolecular interactions, resulting in physically cross-linked polymer networks, whereas the BVZ-loaded hydrogel has a more compact and rigid structure, promoting better entrapment of BVZ. PECs and hydrogel were able to control the BVZ release for 4 and 8 days, respectively. Their release profiles correlated best with the Higuchi and Korsmeyer-Peppas models, respectively, indicating drug diffusion as the limiting step for drug release. Furthermore, BVZ remained biologically active in vitro after its incorporation into the hydrogel system. Together, these studies confirm that PECs and hydrogel exhibit different porous structures and physicochemical properties, making them promising platforms that allow the modulation of BVZ release meeting different requirements.
Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), Araraquara, Rodovia Araraquara–Jaú km 1
I3S–Instituto de Investigação e Inovação em Saúde Universidade do Porto, Rua Alfredo Allen, 208
INEB–Instituto de Engenharia Biomédica Universidade do Porto, Rua Alfredo Allen, 208
CESPU–Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317
ICBAS–Instituto Ciências Biomédicas Abel Salazar Universidade do Porto, Rua de Jorge Viterbo Ferreira 228
Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, Rua Professor Francisco Degni, 55
Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), Araraquara, Rodovia Araraquara–Jaú km 1
Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, Rua Professor Francisco Degni, 55
