Publicação
Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report
| Resumo: | Introduction: Beijing family strains of Mycobacterium tuberculosis are associated with multidrug-resistance. Although strains of the Lisboa family are the most common among multidrug-resistant and extensively drug-resistant patients in the region, several studies have reported the presence of the Beijing family. However, the features of patients from whom they were isolated, are not yet known.Material and Methods: Retrospective study involving 104 multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis, from the same number of patients, isolated and genotyped between 1993 and 2015 in Lisbon. We assessed the prevalence of strains of both families and the epidemiologic and clinical features of those infected with Beijing family strains.Results: Seventy-four strains (71.2%) belonged to the Lisboa family, 25 (24.0%) showed a unique genotypic pattern and five (4.8%) belonged to the Beijing family, the latter identified after 2009. Those infected with Beijing family strains were angolan (n = 1), ukrainian (n = 2) and portuguese (n = 2), mainly young-aged and, four of five immunocompetent and with no past history of tuberculosis. All had multidrug-resistant tuberculosis. We did not find any distinctive clinical or radiological features, neither a predominant resistance pattern. Cure rate was high (four patients).Discussion: Although the number of infected patients with Beijing strains was small, it suggests an important proportion of primary tuberculosis, a potential for transmission in the community but also a better clinical outcome when compared to other reported strains, such as W-Beijing and Lisboa.Conclusion: Although Lisboa family strains account for most of the multidrug and extensively drug-resistant tuberculosis cases in Lisbon area, Beijing strains are transmitted in the city and might change the local characteristics of the epidemics. |
|---|---|
| Autores principais: | Maltez, Fernando |
| Outros Autores: | Martins, Teresa; Póvoas, Diana; Cabo, João; Peres, Helena; Antunes, Francisco; Perdigão, João; Portugal, Isabel |
| Assunto: | Genetic Variation Mycobacterium tuberculosis/genetics Portugal Tuberculosis Multidrug-Resistant Mycobacterium tuberculosis/genética Portugal Tuberculose Resistente a Múltiplos Medicamentos Variação Genética |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Ordem dos Médicos |
| Idioma: | português inglês |
| Origem: | Acta Médica Portuguesa |
| _version_ | 1863896248946262016 |
|---|---|
| author | Maltez, Fernando |
| author2 | Martins, Teresa Póvoas, Diana Cabo, João Peres, Helena Antunes, Francisco Perdigão, João Portugal, Isabel |
| author2_role | author author author author author author author |
| author_facet | Maltez, Fernando Martins, Teresa Póvoas, Diana Cabo, João Peres, Helena Antunes, Francisco Perdigão, João Portugal, Isabel |
| author_role | author |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Maltez, Fernando\"},{\"Person.name\":\"Martins, Teresa\"},{\"Person.name\":\"Póvoas, Diana\"},{\"Person.name\":\"Cabo, João\"},{\"Person.name\":\"Peres, Helena\"},{\"Person.name\":\"Antunes, Francisco\"},{\"Person.name\":\"Perdigão, João\"},{\"Person.name\":\"Portugal, Isabel\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Maltez, Fernando Martins, Teresa Póvoas, Diana Cabo, João Peres, Helena Antunes, Francisco Perdigão, João Portugal, Isabel |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Genetic Variation Mycobacterium tuberculosis/genetics Portugal Tuberculosis Multidrug-Resistant Mycobacterium tuberculosis/genética Portugal Tuberculose Resistente a Múltiplos Medicamentos Variação Genética |
| datacite.titles.title.fl_str_mv | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report Tuberculose Multirresistente por Estirpes da Família Beijing, em Doentes de Lisboa, Portugal: Estudo Preliminar |
| dc.creator.none.fl_str_mv | Maltez, Fernando Martins, Teresa Póvoas, Diana Cabo, João Peres, Helena Antunes, Francisco Perdigão, João Portugal, Isabel |
| dc.description.none.fl_str_mv | Introdução: As estirpes de Mycobacterium tuberculosis da família Beijing estão associadas à multirresistência. As estirpes da família Lisboa prevalecem entre os doentes com tuberculose multirresistente e extensivamente resistente desta região, mas vários estudos documentam a presença da família Beijing, embora desconhecendo-se as características dos doentes donde foram isoladas.Material e Métodos: Estudo retrospectivo de 104 estirpes multirresistentes e extensivamente resistentes de Mycobacterium tuberculosis, isoladas e genotipadas, de 1993 a 2015, de igual número de doentes de Lisboa. Avaliámos a prevalência de ambas as famílias de estirpes e as características epidemiológicas e clínicas, dos infectados por estirpes Beijing.Resultados: Setenta e quatro estirpes (71,2%) pertenciam à família Lisboa, 25 (24,0%) apresentavam padrão genotípico único e cinco (4,8%) pertenciam à família Beijing, estas identificadas depois de 2009. Os infectados pela estirpe Beijing eram de nacionalidade angolana (n = 1), ucraniana (n = 2) e portuguesa (n = 2), na maioria jovens, quatro em cinco imunocompetentes e sem história de tuberculose anterior. Todos tinham tuberculose multirresistente. Não detectámos apresentações clínicas ou radiológicas diferenciadoras, nem padrão de resistências predominante. A taxa de cura foi alta (quatro doentes).Discussão: Apesar do número de doentes infectados pela estirpe Beijing ser reduzido, sugere proporção importante de tuberculose primária, potencial de transmissão na comunidade, mas, também, melhor evolução clínica do que a descrita para outras estirpes, como a W-Beijing ou a Lisboa.Conclusão: Apesar das estirpes da família Lisboa serem as principais responsáveis pelos casos de tuberculose multirresistente e extensivamente resistente na região de Lisboa, as estirpes Beijing transmitem-se na cidade e poderão modificar as características locais da epidemia. |
| dc.format.none.fl_str_mv | application/pdf application/pdf application/msword application/pdf application/msword |
| dc.identifier.none.fl_str_mv | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882 |
| dc.language.none.fl_str_mv | por eng |
| dc.publisher.none.fl_str_mv | Ordem dos Médicos |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Acta Médica Portuguesa; Vol. 30 No. 3 (2017): March; 175-184 Acta Médica Portuguesa; Vol. 30 N.º 3 (2017): Março; 175-184 1646-0758 0870-399X |
| dc.subject.none.fl_str_mv | Genetic Variation Mycobacterium tuberculosis/genetics Portugal Tuberculosis Multidrug-Resistant Mycobacterium tuberculosis/genética Portugal Tuberculose Resistente a Múltiplos Medicamentos Variação Genética |
| dc.title.fl_str_mv | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report Tuberculose Multirresistente por Estirpes da Família Beijing, em Doentes de Lisboa, Portugal: Estudo Preliminar |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: Beijing family strains of Mycobacterium tuberculosis are associated with multidrug-resistance. Although strains of the Lisboa family are the most common among multidrug-resistant and extensively drug-resistant patients in the region, several studies have reported the presence of the Beijing family. However, the features of patients from whom they were isolated, are not yet known.Material and Methods: Retrospective study involving 104 multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis, from the same number of patients, isolated and genotyped between 1993 and 2015 in Lisbon. We assessed the prevalence of strains of both families and the epidemiologic and clinical features of those infected with Beijing family strains.Results: Seventy-four strains (71.2%) belonged to the Lisboa family, 25 (24.0%) showed a unique genotypic pattern and five (4.8%) belonged to the Beijing family, the latter identified after 2009. Those infected with Beijing family strains were angolan (n = 1), ukrainian (n = 2) and portuguese (n = 2), mainly young-aged and, four of five immunocompetent and with no past history of tuberculosis. All had multidrug-resistant tuberculosis. We did not find any distinctive clinical or radiological features, neither a predominant resistance pattern. Cure rate was high (four patients).Discussion: Although the number of infected patients with Beijing strains was small, it suggests an important proportion of primary tuberculosis, a potential for transmission in the community but also a better clinical outcome when compared to other reported strains, such as W-Beijing and Lisboa.Conclusion: Although Lisboa family strains account for most of the multidrug and extensively drug-resistant tuberculosis cases in Lisbon area, Beijing strains are transmitted in the city and might change the local characteristics of the epidemics. |
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| identifier.url.fl_str_mv | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882 |
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| institution | Ordem dos Médicos |
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| person_str_mv | Maltez, Fernando Martins, Teresa Póvoas, Diana Cabo, João Peres, Helena Antunes, Francisco Perdigão, João Portugal, Isabel |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Ordem dos Médicos |
| reponame_str | Acta Médica Portuguesa |
| repository_id_str | urn:repositoryAcronym:amp |
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| spelling | en-USMultidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Reportpt-PTTuberculose Multirresistente por Estirpes da Família Beijing, em Doentes de Lisboa, Portugal: Estudo PreliminarMaltez, FernandoMartins, TeresaPóvoas, DianaCabo, JoãoPeres, HelenaAntunes, FranciscoPerdigão, JoãoPortugal, IsabelGenetic VariationMycobacterium tuberculosis/geneticsPortugalTuberculosisMultidrug-ResistantMycobacterium tuberculosis/genéticaPortugalTuberculose Resistente a Múltiplos MedicamentosVariação GenéticaDireitos de Autor (c) 2017 Acta Médica Portuguesahttp://purl.org/coar/access_right/c_abf2https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882URLhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882/4966URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882/5134URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882/8546URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882/8547URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882/8789URLHasVersion2017-03-31en-USIntroduction: Beijing family strains of Mycobacterium tuberculosis are associated with multidrug-resistance. Although strains of the Lisboa family are the most common among multidrug-resistant and extensively drug-resistant patients in the region, several studies have reported the presence of the Beijing family. However, the features of patients from whom they were isolated, are not yet known.Material and Methods: Retrospective study involving 104 multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis, from the same number of patients, isolated and genotyped between 1993 and 2015 in Lisbon. We assessed the prevalence of strains of both families and the epidemiologic and clinical features of those infected with Beijing family strains.Results: Seventy-four strains (71.2%) belonged to the Lisboa family, 25 (24.0%) showed a unique genotypic pattern and five (4.8%) belonged to the Beijing family, the latter identified after 2009. Those infected with Beijing family strains were angolan (n = 1), ukrainian (n = 2) and portuguese (n = 2), mainly young-aged and, four of five immunocompetent and with no past history of tuberculosis. All had multidrug-resistant tuberculosis. We did not find any distinctive clinical or radiological features, neither a predominant resistance pattern. Cure rate was high (four patients).Discussion: Although the number of infected patients with Beijing strains was small, it suggests an important proportion of primary tuberculosis, a potential for transmission in the community but also a better clinical outcome when compared to other reported strains, such as W-Beijing and Lisboa.Conclusion: Although Lisboa family strains account for most of the multidrug and extensively drug-resistant tuberculosis cases in Lisbon area, Beijing strains are transmitted in the city and might change the local characteristics of the epidemics.pt-PTIntrodução: As estirpes de Mycobacterium tuberculosis da família Beijing estão associadas à multirresistência. As estirpes da família Lisboa prevalecem entre os doentes com tuberculose multirresistente e extensivamente resistente desta região, mas vários estudos documentam a presença da família Beijing, embora desconhecendo-se as características dos doentes donde foram isoladas.Material e Métodos: Estudo retrospectivo de 104 estirpes multirresistentes e extensivamente resistentes de Mycobacterium tuberculosis, isoladas e genotipadas, de 1993 a 2015, de igual número de doentes de Lisboa. Avaliámos a prevalência de ambas as famílias de estirpes e as características epidemiológicas e clínicas, dos infectados por estirpes Beijing.Resultados: Setenta e quatro estirpes (71,2%) pertenciam à família Lisboa, 25 (24,0%) apresentavam padrão genotípico único e cinco (4,8%) pertenciam à família Beijing, estas identificadas depois de 2009. Os infectados pela estirpe Beijing eram de nacionalidade angolana (n = 1), ucraniana (n = 2) e portuguesa (n = 2), na maioria jovens, quatro em cinco imunocompetentes e sem história de tuberculose anterior. Todos tinham tuberculose multirresistente. Não detectámos apresentações clínicas ou radiológicas diferenciadoras, nem padrão de resistências predominante. A taxa de cura foi alta (quatro doentes).Discussão: Apesar do número de doentes infectados pela estirpe Beijing ser reduzido, sugere proporção importante de tuberculose primária, potencial de transmissão na comunidade, mas, também, melhor evolução clínica do que a descrita para outras estirpes, como a W-Beijing ou a Lisboa.Conclusão: Apesar das estirpes da família Lisboa serem as principais responsáveis pelos casos de tuberculose multirresistente e extensivamente resistente na região de Lisboa, as estirpes Beijing transmitem-se na cidade e poderão modificar as características locais da epidemia.Ordem dos Médicosapplication/pdfapplication/pdfapplication/mswordapplication/pdfapplication/msworden-USActa Médica Portuguesa; Vol. 30 No. 3 (2017): March; 175-184pt-PTActa Médica Portuguesa; Vol. 30 N.º 3 (2017): Março; 175-1841646-07580870-399Xporengjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report Maltez, Fernando Genetic Variation Mycobacterium tuberculosis/genetics Portugal Tuberculosis Multidrug-Resistant Mycobacterium tuberculosis/genética Portugal Tuberculose Resistente a Múltiplos Medicamentos Variação Genética |
| status_str | VoR |
| subject.fl_str_mv | Genetic Variation Mycobacterium tuberculosis/genetics Portugal Tuberculosis Multidrug-Resistant Mycobacterium tuberculosis/genética Portugal Tuberculose Resistente a Múltiplos Medicamentos Variação Genética |
| title | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report |
| title_full | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report |
| title_fullStr | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report |
| title_full_unstemmed | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report |
| title_short | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report |
| title_sort | Multidrug-Resistant Tuberculosis by Strains of Beijing Family, in Patients from Lisbon, Portugal: Preliminary Report |
| topic | Genetic Variation Mycobacterium tuberculosis/genetics Portugal Tuberculosis Multidrug-Resistant Mycobacterium tuberculosis/genética Portugal Tuberculose Resistente a Múltiplos Medicamentos Variação Genética |
| topic_facet | Genetic Variation Mycobacterium tuberculosis/genetics Portugal Tuberculosis Multidrug-Resistant Mycobacterium tuberculosis/genética Portugal Tuberculose Resistente a Múltiplos Medicamentos Variação Genética |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7882 |
| visible | 1 |