Publicação
Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy
| Resumo: | Introduction: Sentinel lymph node biopsy is currently the standard surgical procedure for lymph node staging in patients with early stage breast cancer. It is performed using different techniques, such as the injection of vital dyes and / or radioisotopes and, more recently, guided by fluorescence using Indocyanine green. The aim of this study is to assess the detection rate of sentinel lymph node using Indocyanine green in breast cancer patients according to factors related to the patient and the tumor.Material and Methods: Retrospective study of a random sample of patients with breast cancer, treated and followed at Centro Hospitalar São João, in Porto, between 2012 and 2016.Results: Indocyanine green detection rate was over 90% and its diagnostic accuracy was similar to other methods described in the presence of metastatic involvement of lymph nodes.Discussion: There was no statistically significant difference between the three methods in the detection rates in subgroups of older women, with normal weight and in those who underwent previous surgery in breast or axilla or neo-adjuvant chemotherapy.Conclusion: Indocyanine green is a potential alternative method to other sentinel lymph node screening techniques, appearing as a future option for breast cancer centers with no nuclear medicine department. However, it is essential to carry out further research in order to define the ideal patients’ profile that maximizes the method’s effectiveness. |
|---|---|
| Autores principais: | Vaz, Teresa |
| Outros Autores: | Costa, Susy; Peleteiro, Bárbara |
| Assunto: | Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Ordem dos Médicos |
| Idioma: | português inglês |
| Origem: | Acta Médica Portuguesa |
| _version_ | 1865920042921623552 |
|---|---|
| author | Vaz, Teresa |
| author2 | Costa, Susy Peleteiro, Bárbara |
| author2_role | author author |
| author_facet | Vaz, Teresa Vaz, Teresa Costa, Susy Peleteiro, Bárbara Costa, Susy Peleteiro, Bárbara |
| author_role | author |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Vaz, Teresa\"},{\"Person.name\":\"Costa, Susy\"},{\"Person.name\":\"Peleteiro, Bárbara\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Vaz, Teresa Costa, Susy Peleteiro, Bárbara |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina |
| datacite.titles.title.fl_str_mv | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy Biópsia do Gânglio Sentinela Guiada por Fluorescência no Cancro da Mama: Taxa de Deteção e Performance Diagnóstica |
| dc.creator.none.fl_str_mv | Vaz, Teresa Costa, Susy Peleteiro, Bárbara |
| dc.description.none.fl_str_mv | Introdução: A biópsia do gânglio sentinela é atualmente o procedimento cirúrgico standard para o estadiamento ganglionar em doentes com cancro da mama em estádio precoce, sendo realizado com recurso a diferentes técnicas, como a injeção de corantes vitais e/ou de radioisótopos e, mais recentemente, guiada por fluorescência utilizando o verde de indocianina. O objetivo deste estudo é avaliar a acuidade global do verde de indocianina na identificação do gânglio sentinela em doentes com cancro da mama e de acordo com fatores relacionados com a doente e com o tumor.Material e Métodos: Estudo retrospetivo numa amostra aleatória de doentes com cancro da mama seguidas e tratadas no Centro Hospitalar São João no período entre 2012 e 2016.Resultados: Obtivemos uma taxa de deteção do gânglio sentinela no cancro da mama pelo verde de indocianina superior a 90% e uma performance diagnóstica deste método similar às outras técnicas descritas na presença de metástases ganglionares. Discussão: Não se verificaram diferenças estatisticamente significativas entre os três métodos relativamente às taxas de deteção no subgrupo de mulheres mais velhas, normoponderais, nas que tinham realizado tratamento prévio à mama ou à axila e nas que foram submetidas a quimioterapia neo-adjuvante.Conclusão: O verde de indocianina é um potencial método alternativo a outras técnicas de pesquisa do gânglio sentinela, afigurando-se como opção futura para os hospitais que não possuem serviço de Medicina Nuclear. Contudo, é essencial a realização de novos estudos no sentido de definir o perfil das doentes que maximiza a sua eficácia. |
| dc.format.none.fl_str_mv | application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395 |
| dc.language.none.fl_str_mv | por eng |
| dc.publisher.none.fl_str_mv | Ordem dos Médicos |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Acta Médica Portuguesa; Vol. 31 No. 12 (2018): December; 706-713 Acta Médica Portuguesa; Vol. 31 N.º 12 (2018): Dezembro; 706-713 1646-0758 0870-399X |
| dc.subject.none.fl_str_mv | Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina |
| dc.title.fl_str_mv | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy Biópsia do Gânglio Sentinela Guiada por Fluorescência no Cancro da Mama: Taxa de Deteção e Performance Diagnóstica |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: Sentinel lymph node biopsy is currently the standard surgical procedure for lymph node staging in patients with early stage breast cancer. It is performed using different techniques, such as the injection of vital dyes and / or radioisotopes and, more recently, guided by fluorescence using Indocyanine green. The aim of this study is to assess the detection rate of sentinel lymph node using Indocyanine green in breast cancer patients according to factors related to the patient and the tumor.Material and Methods: Retrospective study of a random sample of patients with breast cancer, treated and followed at Centro Hospitalar São João, in Porto, between 2012 and 2016.Results: Indocyanine green detection rate was over 90% and its diagnostic accuracy was similar to other methods described in the presence of metastatic involvement of lymph nodes.Discussion: There was no statistically significant difference between the three methods in the detection rates in subgroups of older women, with normal weight and in those who underwent previous surgery in breast or axilla or neo-adjuvant chemotherapy.Conclusion: Indocyanine green is a potential alternative method to other sentinel lymph node screening techniques, appearing as a future option for breast cancer centers with no nuclear medicine department. However, it is essential to carry out further research in order to define the ideal patients’ profile that maximizes the method’s effectiveness. |
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| eu_rights_str_mv | unknown |
| format | article |
| id | amp_77a1bd5dca0ff8db218d00bd8b3fee9e |
| identifier.url.fl_str_mv | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395 |
| instacron_str | om |
| institution | Ordem dos Médicos |
| instname_str | Ordem dos Médicos |
| language | por eng |
| network_acronym_str | amp |
| network_name_str | Acta Médica Portuguesa |
| oai_identifier_str | oai:ojs.www.actamedicaportuguesa.com:article/10395 |
| organization_str_mv | urn:organizationAcronym:om |
| person_str_mv | Vaz, Teresa Costa, Susy Peleteiro, Bárbara |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Ordem dos Médicos |
| reponame_str | Acta Médica Portuguesa |
| repository_id_str | urn:repositoryAcronym:amp |
| service_str_mv | urn:repositoryAcronym:amp |
| spelling | en-USFluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracypt-PTBiópsia do Gânglio Sentinela Guiada por Fluorescência no Cancro da Mama: Taxa de Deteção e Performance DiagnósticaVaz, TeresaCosta, SusyPeleteiro, BárbaraBreast NeoplasmsIndocyanine GreenSentinel Lymph Node BiopsyBiópsia do Gânglio SentinelaNeoplasias da MamaVerde de IndocianinaDireitos de Autor (c) 2018 Acta Médica Portuguesahttp://purl.org/coar/access_right/c_abf2https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395URLhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395/5554URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395/6063URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395/10045URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395/10046URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395/10347URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395/10770URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395/10772URLHasVersion2018-12-28en-USIntroduction: Sentinel lymph node biopsy is currently the standard surgical procedure for lymph node staging in patients with early stage breast cancer. It is performed using different techniques, such as the injection of vital dyes and / or radioisotopes and, more recently, guided by fluorescence using Indocyanine green. The aim of this study is to assess the detection rate of sentinel lymph node using Indocyanine green in breast cancer patients according to factors related to the patient and the tumor.Material and Methods: Retrospective study of a random sample of patients with breast cancer, treated and followed at Centro Hospitalar São João, in Porto, between 2012 and 2016.Results: Indocyanine green detection rate was over 90% and its diagnostic accuracy was similar to other methods described in the presence of metastatic involvement of lymph nodes.Discussion: There was no statistically significant difference between the three methods in the detection rates in subgroups of older women, with normal weight and in those who underwent previous surgery in breast or axilla or neo-adjuvant chemotherapy.Conclusion: Indocyanine green is a potential alternative method to other sentinel lymph node screening techniques, appearing as a future option for breast cancer centers with no nuclear medicine department. However, it is essential to carry out further research in order to define the ideal patients’ profile that maximizes the method’s effectiveness.pt-PTIntrodução: A biópsia do gânglio sentinela é atualmente o procedimento cirúrgico standard para o estadiamento ganglionar em doentes com cancro da mama em estádio precoce, sendo realizado com recurso a diferentes técnicas, como a injeção de corantes vitais e/ou de radioisótopos e, mais recentemente, guiada por fluorescência utilizando o verde de indocianina. O objetivo deste estudo é avaliar a acuidade global do verde de indocianina na identificação do gânglio sentinela em doentes com cancro da mama e de acordo com fatores relacionados com a doente e com o tumor.Material e Métodos: Estudo retrospetivo numa amostra aleatória de doentes com cancro da mama seguidas e tratadas no Centro Hospitalar São João no período entre 2012 e 2016.Resultados: Obtivemos uma taxa de deteção do gânglio sentinela no cancro da mama pelo verde de indocianina superior a 90% e uma performance diagnóstica deste método similar às outras técnicas descritas na presença de metástases ganglionares. Discussão: Não se verificaram diferenças estatisticamente significativas entre os três métodos relativamente às taxas de deteção no subgrupo de mulheres mais velhas, normoponderais, nas que tinham realizado tratamento prévio à mama ou à axila e nas que foram submetidas a quimioterapia neo-adjuvante.Conclusão: O verde de indocianina é um potencial método alternativo a outras técnicas de pesquisa do gânglio sentinela, afigurando-se como opção futura para os hospitais que não possuem serviço de Medicina Nuclear. Contudo, é essencial a realização de novos estudos no sentido de definir o perfil das doentes que maximiza a sua eficácia.Ordem dos Médicosapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfen-USActa Médica Portuguesa; Vol. 31 No. 12 (2018): December; 706-713pt-PTActa Médica Portuguesa; Vol. 31 N.º 12 (2018): Dezembro; 706-7131646-07580870-399Xporengjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy Vaz, Teresa Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina Vaz, Teresa Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina |
| status | NEW |
| status_str | VoR |
| subject.fl_str_mv | Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina |
| title | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy |
| title_full | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy |
| title_fullStr | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy |
| title_full_unstemmed | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy |
| title_short | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy |
| title_sort | Fluorescence-Guided Sentinel Lymph Node Biopsy in Breast Cancer: Detection Rate and Diagnostic Accuracy |
| topic | Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina |
| topic_facet | Breast Neoplasms Indocyanine Green Sentinel Lymph Node Biopsy Biópsia do Gânglio Sentinela Neoplasias da Mama Verde de Indocianina |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10395 |
| visible | 1 |