Publicação
Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour
| Resumo: | The carcinoid syndrome is rare but it is associated with carcinoid heart disease in more than a half of the cases. Carcinoid heart disease is typically characterised by morphological and functional modifications of right-sided valves. Its aetiology is probable multifactorial but serotonin appears to play a key role in the development of this valvular disease. Unlike gastrointestinal neuroendocrine tumours, ovarian neuroendocrine tumours can present with carcinoid syndrome and carcinoid heart disease in the absence of liver metastases; such ovarian neuroendocrine tumours are a unique clinical entity. The additional burden of cardiac impairment in these patients represents a significant reduction in survival. Early recognition and surgical valve replacement before advanced heart failure is established may improve the clinical outcome. We report the case of a woman with an ovarian neuroendocrine tumour and highly symptomatic carcinoid heart disease who was submitted to tumour resection followed by valvuloplasty. She demonstrated an outstanding clinical improvement and has remained free of tumour and symptomatology. |
|---|---|
| Autores principais: | Simões-Pereira, Joana |
| Outros Autores: | Wang, Lai Mun; Kardos, Attila; Grossman, Ashley |
| Assunto: | Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Ordem dos Médicos |
| Idioma: | inglês |
| Origem: | Acta Médica Portuguesa |
| _version_ | 1865920043089395712 |
|---|---|
| author | Simões-Pereira, Joana |
| author2 | Wang, Lai Mun Kardos, Attila Grossman, Ashley |
| author2_role | author author author |
| author_facet | Simões-Pereira, Joana Simões-Pereira, Joana Wang, Lai Mun Kardos, Attila Grossman, Ashley Wang, Lai Mun Kardos, Attila Grossman, Ashley |
| author_role | author |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Simões-Pereira, Joana\"},{\"Person.name\":\"Wang, Lai Mun\"},{\"Person.name\":\"Kardos, Attila\"},{\"Person.name\":\"Grossman, Ashley\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Simões-Pereira, Joana Wang, Lai Mun Kardos, Attila Grossman, Ashley |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
| datacite.titles.title.fl_str_mv | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Síndrome Carcinoide e Doença Carcinoide Cardíaca como Manifestações de Tumor Neuroendócrino do Ovário Não Metastático |
| dc.creator.none.fl_str_mv | Simões-Pereira, Joana Wang, Lai Mun Kardos, Attila Grossman, Ashley |
| dc.description.none.fl_str_mv | A síndrome carcinoide é rara mas encontra-se associada, em cerca de metade dos casos, a doença carcinoide cardíaca. Esta patologia cardíaca caracteriza-se tipicamente por alterações morfo-funcionais das válvulas direitas. A sua etiologia é provavelmente multifatorial mas, aparentemente, a serotonina parece exercer um papel preponderante no desenvolvimento desta doença valvular. Ao contrário dos tumores neuroendócrinos gastrointestinais, os tumores neuroendócrinos do ovário podem apresentar síndrome carcinoide e doença carcinoide cardíaca na ausência de metastização hepática, tornando os tumores neuroendócrinos do ovário uma entidade clínica única. Estas alterações cardíacas acarretam uma diminuição adicional da sobrevivência destes doentes. Portanto, o reconhecimento precoce desta entidade e a substituição valvular prévia ao estabelecimento da insuficiência cardíaca avançada podem melhorar a evolução clínica destes doentes. Os autores apresentam o caso de uma mulher com tumor neuroendócrino do ovário e doença carcinoide cardíaca muito sintomática que foi submetida a resseção tumoral seguida de valvuloplastia. A doente demonstrou uma marcada melhoria clínica e tem permanecido livre de doença e assintomática. |
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| dc.identifier.none.fl_str_mv | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Ordem dos Médicos |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Acta Médica Portuguesa; Vol. 30 No. 5 (2017): May; 421-425 Acta Médica Portuguesa; Vol. 30 N.º 5 (2017): Maio; 421-425 1646-0758 0870-399X |
| dc.subject.none.fl_str_mv | Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
| dc.title.fl_str_mv | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Síndrome Carcinoide e Doença Carcinoide Cardíaca como Manifestações de Tumor Neuroendócrino do Ovário Não Metastático |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The carcinoid syndrome is rare but it is associated with carcinoid heart disease in more than a half of the cases. Carcinoid heart disease is typically characterised by morphological and functional modifications of right-sided valves. Its aetiology is probable multifactorial but serotonin appears to play a key role in the development of this valvular disease. Unlike gastrointestinal neuroendocrine tumours, ovarian neuroendocrine tumours can present with carcinoid syndrome and carcinoid heart disease in the absence of liver metastases; such ovarian neuroendocrine tumours are a unique clinical entity. The additional burden of cardiac impairment in these patients represents a significant reduction in survival. Early recognition and surgical valve replacement before advanced heart failure is established may improve the clinical outcome. We report the case of a woman with an ovarian neuroendocrine tumour and highly symptomatic carcinoid heart disease who was submitted to tumour resection followed by valvuloplasty. She demonstrated an outstanding clinical improvement and has remained free of tumour and symptomatology. |
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| identifier.url.fl_str_mv | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713 |
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| institution | Ordem dos Médicos |
| instname_str | Ordem dos Médicos |
| language | eng |
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| organization_str_mv | urn:organizationAcronym:om |
| person_str_mv | Simões-Pereira, Joana Wang, Lai Mun Kardos, Attila Grossman, Ashley |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Ordem dos Médicos |
| reponame_str | Acta Médica Portuguesa |
| repository_id_str | urn:repositoryAcronym:amp |
| service_str_mv | urn:repositoryAcronym:amp |
| spelling | en-USCarcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumourpt-PTSíndrome Carcinoide e Doença Carcinoide Cardíaca como Manifestações de Tumor Neuroendócrino do Ovário Não MetastáticoSimões-Pereira, JoanaWang, Lai MunKardos, AttilaGrossman, AshleyCarcinomaNeuroendocrineCarcinoid Heart DiseaseCarcinoid TumorOvarian NeoplasmsCarcinoma NeuroendócrinoDoença Carcinoide CardíacaNeoplasias do OvárioTumor CarcinoideDireitos de Autor (c) 2017 Acta Médica Portuguesahttp://purl.org/coar/access_right/c_abf2https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713URLhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/5051URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8421URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8422URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8736URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8737URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8738URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8739URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8740URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8864URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8865URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8866URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8867URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8868URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8869URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8914URLHasVersionhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713/8915URLHasVersion2017-05-31en-USThe carcinoid syndrome is rare but it is associated with carcinoid heart disease in more than a half of the cases. Carcinoid heart disease is typically characterised by morphological and functional modifications of right-sided valves. Its aetiology is probable multifactorial but serotonin appears to play a key role in the development of this valvular disease. Unlike gastrointestinal neuroendocrine tumours, ovarian neuroendocrine tumours can present with carcinoid syndrome and carcinoid heart disease in the absence of liver metastases; such ovarian neuroendocrine tumours are a unique clinical entity. The additional burden of cardiac impairment in these patients represents a significant reduction in survival. Early recognition and surgical valve replacement before advanced heart failure is established may improve the clinical outcome. We report the case of a woman with an ovarian neuroendocrine tumour and highly symptomatic carcinoid heart disease who was submitted to tumour resection followed by valvuloplasty. She demonstrated an outstanding clinical improvement and has remained free of tumour and symptomatology.pt-PTA síndrome carcinoide é rara mas encontra-se associada, em cerca de metade dos casos, a doença carcinoide cardíaca. Esta patologia cardíaca caracteriza-se tipicamente por alterações morfo-funcionais das válvulas direitas. A sua etiologia é provavelmente multifatorial mas, aparentemente, a serotonina parece exercer um papel preponderante no desenvolvimento desta doença valvular. Ao contrário dos tumores neuroendócrinos gastrointestinais, os tumores neuroendócrinos do ovário podem apresentar síndrome carcinoide e doença carcinoide cardíaca na ausência de metastização hepática, tornando os tumores neuroendócrinos do ovário uma entidade clínica única. Estas alterações cardíacas acarretam uma diminuição adicional da sobrevivência destes doentes. Portanto, o reconhecimento precoce desta entidade e a substituição valvular prévia ao estabelecimento da insuficiência cardíaca avançada podem melhorar a evolução clínica destes doentes. Os autores apresentam o caso de uma mulher com tumor neuroendócrino do ovário e doença carcinoide cardíaca muito sintomática que foi submetida a resseção tumoral seguida de valvuloplastia. A doente demonstrou uma marcada melhoria clínica e tem permanecido livre de doença e assintomática.Ordem dos Médicosapplication/pdfimage/jpegapplication/mswordimage/jpegimage/jpegimage/jpegimage/jpegapplication/mswordapplication/mswordimage/tiffimage/tiffimage/jpegimage/jpegimage/jpegapplication/pdfapplication/pdfen-USActa Médica Portuguesa; Vol. 30 No. 5 (2017): May; 421-425pt-PTActa Médica Portuguesa; Vol. 30 N.º 5 (2017): Maio; 421-4251646-07580870-399Xengjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Simões-Pereira, Joana Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide Simões-Pereira, Joana Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
| status | NEW |
| status_str | VoR |
| subject.fl_str_mv | Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
| title | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
| title_full | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
| title_fullStr | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
| title_full_unstemmed | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
| title_short | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
| title_sort | Carcinoid Syndrome and Carcinoid Heart Disease as Manifestations of Non-Metastatic Ovarian Neuroendocrine Tumour |
| topic | Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
| topic_facet | Carcinoma Neuroendocrine Carcinoid Heart Disease Carcinoid Tumor Ovarian Neoplasms Carcinoma Neuroendócrino Doença Carcinoide Cardíaca Neoplasias do Ovário Tumor Carcinoide |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7713 |
| visible | 1 |