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Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment

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Detalhes bibliográficos
Resumo:Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.
Autores principais:Moreira, Susana
Outros Autores:Rodrigues, Raquel; Barros, André B.; Pejanovic, Nadja; Neves-Costa, Ana; Pedroso, Dora; Pereira, Cláudia; Fernandes, Dina; Rodrigues, João Valença; Barbara, Cristina; Moita, Luís Ferreira
Assunto:obstructive sleep apnea syndrome clock genes continuous positive airway pressure slow wave sleep Metabolic Syndrome Circadian Rhythms
Ano:2017
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Repositório do GIMM – Gulbenkian Institute for Molecular Medicine
Idioma:inglês
Origem:ARCA
Descrição
Resumo:Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.

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