Publicação
Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3
| Resumo: | Mechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet. In this study, the relationship between repertoires of circulating self-reactive and parasite-specific immunoglobulin G (IgG), their correlation with cytokine levels, and their association with protection against malaria was investigated in asymptomatic Plasmodium falciparum-infected Gabonese children. |
|---|---|
| Autores principais: | Guiyedi, Vincent |
| Outros Autores: | Bécavin, Christophe; Herbert, Fabien; Gray, Julian; Cazenave, Pierre-André; Kombila, Maryvonne; Crisanti, Andrea; Fesel, Constantin; Pied, Sylviane |
| Assunto: | Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| Idioma: | inglês |
| Origem: | ARCA |
| _version_ | 1867149333712863232 |
|---|---|
| author | Guiyedi, Vincent |
| author2 | Bécavin, Christophe Herbert, Fabien Gray, Julian Cazenave, Pierre-André Kombila, Maryvonne Crisanti, Andrea Fesel, Constantin Pied, Sylviane |
| author2_role | author author author author author author author author |
| author_facet | Guiyedi, Vincent Bécavin, Christophe Herbert, Fabien Gray, Julian Cazenave, Pierre-André Kombila, Maryvonne Crisanti, Andrea Fesel, Constantin Pied, Sylviane |
| author_role | author |
| contributor_name_str_mv | ARCA |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Guiyedi, Vincent\"},{\"Person.name\":\"Bécavin, Christophe\"},{\"Person.name\":\"Herbert, Fabien\"},{\"Person.name\":\"Gray, Julian\"},{\"Person.name\":\"Cazenave, Pierre-André\"},{\"Person.name\":\"Kombila, Maryvonne\"},{\"Person.name\":\"Crisanti, Andrea\"},{\"Person.name\":\"Fesel, Constantin\"},{\"Person.name\":\"Pied, Sylviane\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | ARCA |
| datacite.creators.creator.creatorName.fl_str_mv | Guiyedi, Vincent Bécavin, Christophe Herbert, Fabien Gray, Julian Cazenave, Pierre-André Kombila, Maryvonne Crisanti, Andrea Fesel, Constantin Pied, Sylviane |
| datacite.date.Accepted.fl_str_mv | 2015-04-16T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-10-20T14:54:06Z |
| datacite.date.embargoed.fl_str_mv | 2015-10-20T14:54:06Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines |
| datacite.titles.title.fl_str_mv | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| dc.contributor.none.fl_str_mv | ARCA |
| dc.creator.none.fl_str_mv | Guiyedi, Vincent Bécavin, Christophe Herbert, Fabien Gray, Julian Cazenave, Pierre-André Kombila, Maryvonne Crisanti, Andrea Fesel, Constantin Pied, Sylviane |
| dc.date.Accepted.fl_str_mv | 2015-04-16T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-10-20T14:54:06Z |
| dc.date.embargoed.fl_str_mv | 2015-10-20T14:54:06Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.7/413 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | BioMed Central |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines |
| dc.title.fl_str_mv | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Mechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet. In this study, the relationship between repertoires of circulating self-reactive and parasite-specific immunoglobulin G (IgG), their correlation with cytokine levels, and their association with protection against malaria was investigated in asymptomatic Plasmodium falciparum-infected Gabonese children. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://arca.gimm.pt/bitstreams/f0f6aee0-36de-4f73-8b9b-df0cdb4f4d4f/download |
| id | arca_2a5d1fa87f2d7ac5ee5ee980e85566fe |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.7/413 |
| instacron_str | arca |
| institution | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| instname_str | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| language | eng |
| network_acronym_str | arca |
| network_name_str | ARCA |
| oai_identifier_str | oai:arca.gimm.pt:10400.7/413 |
| organization_str_mv | urn:organizationAcronym:arca |
| person_str_mv | Guiyedi, Vincent Bécavin, Christophe Herbert, Fabien Gray, Julian Cazenave, Pierre-André Kombila, Maryvonne Crisanti, Andrea Fesel, Constantin Pied, Sylviane |
| publishDate | 2015 |
| publisher.none.fl_str_mv | BioMed Central |
| reponame_str | ARCA |
| repository_id_str | urn:repositoryAcronym:arca |
| service_str_mv | urn:repositoryAcronym:arca |
| spelling | engBioMed Centralpt_PTMechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet. In this study, the relationship between repertoires of circulating self-reactive and parasite-specific immunoglobulin G (IgG), their correlation with cytokine levels, and their association with protection against malaria was investigated in asymptomatic Plasmodium falciparum-infected Gabonese children.application/pdfpt_PTAsymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3Guiyedi, VincentBécavin, ChristopheHerbert, FabienGray, JulianCazenave, Pierre-AndréKombila, MaryvonneCrisanti, AndreaFesel, ConstantinPied, SylvianeHostingInstitutionOrganizationalARCAe-mailmailto:arca.repository@gimm.ptarca.repository@gimm.ptDOIIsPartOf10.1186/s12936-015-0658-72015-10-20T14:54:06Z2015-04-162015-04-16T00:00:00ZHandlehttp://hdl.handle.net/10400.7/413http://purl.org/coar/access_right/c_abf2open accessAuto-antibodyAntibody responsePlasmodium falciparumMalariaCytokines1415019 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2015-04-16http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://arca.gimm.pt/bitstreams/f0f6aee0-36de-4f73-8b9b-df0cdb4f4d4f/downloadMalaria Journal14111 |
| spellingShingle | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 Guiyedi, Vincent Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines |
| status | SINGLETON |
| subject.fl_str_mv | Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines |
| title | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| title_full | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| title_fullStr | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| title_full_unstemmed | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| title_short | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| title_sort | Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 |
| topic | Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines |
| topic_facet | Auto-antibody Antibody response Plasmodium falciparum Malaria Cytokines |
| url | http://hdl.handle.net/10400.7/413 |
| visible | 1 |