Publicação
Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia
| Resumo: | Haemoglobin S (HbS) is the gene known to confer the strongest advantage against malaria morbidity and mortality. Multiple HbS effects have been described resulting in protection against parasitaemia and reduction of severe malaria risk. This study aimed to explore HbS protection against severe malaria and Plasmodium falciparum parasitaemia in Angolan children exhibiting different severe malaria syndromes. |
|---|---|
| Autores principais: | do Sambo, Maria Rosário |
| Outros Autores: | Penha-Gonçalves, Carlos; Trovoada, Maria Jesus; Costa, João; Lardoeyt, Roberto; Coutinho, António |
| Assunto: | Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| Idioma: | inglês |
| Origem: | ARCA |
| _version_ | 1868974516028309504 |
|---|---|
| author | do Sambo, Maria Rosário |
| author2 | Penha-Gonçalves, Carlos Trovoada, Maria Jesus Costa, João Lardoeyt, Roberto Coutinho, António |
| author2_role | author author author author author |
| author_facet | do Sambo, Maria Rosário Penha-Gonçalves, Carlos Trovoada, Maria Jesus Costa, João Lardoeyt, Roberto Coutinho, António |
| author_role | author |
| contributor_name_str_mv | ARCA |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"do Sambo, Maria Rosário\"},{\"Person.name\":\"Penha-Gonçalves, Carlos\"},{\"Person.name\":\"Trovoada, Maria Jesus\"},{\"Person.name\":\"Costa, João\"},{\"Person.name\":\"Lardoeyt, Roberto\"},{\"Person.name\":\"Coutinho, António\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | ARCA |
| datacite.creators.creator.creatorName.fl_str_mv | do Sambo, Maria Rosário Penha-Gonçalves, Carlos Trovoada, Maria Jesus Costa, João Lardoeyt, Roberto Coutinho, António |
| datacite.date.Accepted.fl_str_mv | 2015-10-07T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-11-17T15:54:52Z |
| datacite.date.embargoed.fl_str_mv | 2015-11-17T15:54:52Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| datacite.titles.title.fl_str_mv | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| dc.contributor.none.fl_str_mv | ARCA |
| dc.creator.none.fl_str_mv | do Sambo, Maria Rosário Penha-Gonçalves, Carlos Trovoada, Maria Jesus Costa, João Lardoeyt, Roberto Coutinho, António |
| dc.date.Accepted.fl_str_mv | 2015-10-07T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-11-17T15:54:52Z |
| dc.date.embargoed.fl_str_mv | 2015-11-17T15:54:52Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.7/498 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | BioMed Central |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| dc.title.fl_str_mv | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Haemoglobin S (HbS) is the gene known to confer the strongest advantage against malaria morbidity and mortality. Multiple HbS effects have been described resulting in protection against parasitaemia and reduction of severe malaria risk. This study aimed to explore HbS protection against severe malaria and Plasmodium falciparum parasitaemia in Angolan children exhibiting different severe malaria syndromes. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://arca.gimm.pt/bitstreams/079a6db5-66a5-4684-9cc5-66671c1cd261/download |
| id | arca_bb62a4e678481adeef0ec446d74fd71a |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.7/498 |
| inst_facet_str | urn:organizationAcronym:arca{{{_:::_}}}Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| instacron_str | arca |
| institution | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| instname_str | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| language | eng |
| network_acronym_str | arca |
| network_name_str | ARCA |
| oai_identifier_str | oai:arca.gimm.pt:10400.7/498 |
| organization_str_mv | urn:organizationAcronym:arca |
| person_str_mv | do Sambo, Maria Rosário Penha-Gonçalves, Carlos Trovoada, Maria Jesus Costa, João Lardoeyt, Roberto Coutinho, António |
| publishDate | 2015 |
| publisher.none.fl_str_mv | BioMed Central |
| repo_facet_str | urn:repositoryAcronym:arca{{{_:::_}}}ARCA |
| reponame_str | ARCA |
| repository_id_str | urn:repositoryAcronym:arca |
| service_str_mv | urn:repositoryAcronym:arca |
| spelling | engBioMed Centralpt_PTHaemoglobin S (HbS) is the gene known to confer the strongest advantage against malaria morbidity and mortality. Multiple HbS effects have been described resulting in protection against parasitaemia and reduction of severe malaria risk. This study aimed to explore HbS protection against severe malaria and Plasmodium falciparum parasitaemia in Angolan children exhibiting different severe malaria syndromes.application/pdfpt_PTQuantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemiado Sambo, Maria RosárioPenha-Gonçalves, CarlosTrovoada, Maria JesusCosta, JoãoLardoeyt, RobertoCoutinho, AntónioHostingInstitutionOrganizationalARCAe-mailmailto:arca.repository@gimm.ptarca.repository@gimm.ptDOIIsPartOf10.1186/s12936-015-0920-z2015-11-17T15:54:52Z2015-10-072015-10-07T00:00:00ZHandlehttp://hdl.handle.net/10400.7/498http://purl.org/coar/access_right/c_abf2open accessMalariaSickle cellHyperparasitaemiaSevere malariaHbSAngola1108633 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2015-10-07http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://arca.gimm.pt/bitstreams/079a6db5-66a5-4684-9cc5-66671c1cd261/downloadMalaria Journal14118 |
| spellingShingle | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia do Sambo, Maria Rosário Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| status | SINGLETON |
| subject.fl_str_mv | Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| title | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| title_full | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| title_fullStr | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| title_full_unstemmed | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| title_short | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| title_sort | Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia |
| topic | Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| topic_facet | Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| url | http://hdl.handle.net/10400.7/498 |
| visible | 1 |