Publicação
Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia
| Resumo: | Haemoglobin S (HbS) is the gene known to confer the strongest advantage against malaria morbidity and mortality. Multiple HbS effects have been described resulting in protection against parasitaemia and reduction of severe malaria risk. This study aimed to explore HbS protection against severe malaria and Plasmodium falciparum parasitaemia in Angolan children exhibiting different severe malaria syndromes. |
|---|---|
| Autores principais: | do Sambo, Maria Rosário |
| Outros Autores: | Penha-Gonçalves, Carlos; Trovoada, Maria Jesus; Costa, João; Lardoeyt, Roberto; Coutinho, António |
| Assunto: | Malaria Sickle cell Hyperparasitaemia Severe malaria HbS Angola |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
| Idioma: | inglês |
| Origem: | ARCA |
Registos relacionados
groups Haemolysis in sickle cell anaemia: a genotype/phenotype association study
por: Lavinha, João
Publicado em: (2012)
por: Lavinha, João
Publicado em: (2012)
article Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
por: Herbert, Fabien
Publicado em: (2015)
por: Herbert, Fabien
Publicado em: (2015)
article Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status
por: Duarte, J.
Publicado em: (2007)
por: Duarte, J.
Publicado em: (2007)
article Formas Malignas de Malária por Plasmodium Falciparum
por: Palmeiro Ribeiro, J
Publicado em: (1986)
por: Palmeiro Ribeiro, J
Publicado em: (1986)
article Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak
por: Da Veiga Leal, Silvania
Publicado em: (2021)
por: Da Veiga Leal, Silvania
Publicado em: (2021)
article Clusters of cytokines determine malaria severity in Plasmodium falciparum - Infected patients from endemic areas of central India
por: Prakash, D.
Publicado em: (2006)
por: Prakash, D.
Publicado em: (2006)
article O rastreio nacional neonatal da drepanocitose e a comunicação do estado de portador
por: Fernandes da Rocha, Diogo
Publicado em: (2023)
por: Fernandes da Rocha, Diogo
Publicado em: (2023)
article Plasmodium falciparum malaria, bilateral sixth cranial nerve palsy and delayed cerebellar ataxia
por: Duque, V
Publicado em: (2012)
por: Duque, V
Publicado em: (2012)
school Caracterização de factores de risco da malária placentária por Plasmodium falciparum em Luanda
por: CAMPOS, Paulo Adão de
Publicado em: (2011)
por: CAMPOS, Paulo Adão de
Publicado em: (2011)
school Interaction of malaria parasites with host late endocytic and autophagic pathways is essential for Plasmodium liver stage development
por: Matos, Carolina Thieleke da Silva Macedo
Publicado em: (2013)
por: Matos, Carolina Thieleke da Silva Macedo
Publicado em: (2013)
school Evaluation of novel molecular markers for monitoring drug resistence in Plasmodium falciparum malaria
por: Henriques, Gisela Cristina Lourenço
Publicado em: (2010)
por: Henriques, Gisela Cristina Lourenço
Publicado em: (2010)
article Generation of a genetically modified chimeric plasmodium falciparum parasite expressing plasmodium vivax circumsporozoite protein for malaria vaccine development
por: Miyazaki, Yukiko
Publicado em: (2020)
por: Miyazaki, Yukiko
Publicado em: (2020)
category On-chip optical microsystem for Plasmodium falciparum malaria detection
por: Baptista, Vitória Cunha
Publicado em: (2024)
por: Baptista, Vitória Cunha
Publicado em: (2024)
article A Difficult Diagnosis of Plasmodium ovale Malaria
por: Santos-Reis, Ana
Publicado em: (2022)
por: Santos-Reis, Ana
Publicado em: (2022)
school Avaliação da atividade de novas alquil-ciclohexanonas de Poupartia borbonica sobre Plasmodium falciparum
por: Mamede, Lúcia Cristina Coelho Cristino
Publicado em: (2017)
por: Mamede, Lúcia Cristina Coelho Cristino
Publicado em: (2017)
school Proteínas recombinantes de Plasmodium Falciparum para deteção de malária por nanoimunoensaios
por: Silva, Isabel Bernardo Gonçalves Oliveira
Publicado em: (2013)
por: Silva, Isabel Bernardo Gonçalves Oliveira
Publicado em: (2013)
school Cerebral malaria: Plasmodium falciparum effect on human brain microvascular endothelial cells and brain organoids
por: Pedrosa, Ana Rita Silva
Publicado em: (2023)
por: Pedrosa, Ana Rita Silva
Publicado em: (2023)
category Dynamics of plasmodium falciparum selection after Artemether-Lumefantrine treatment in Africa
por: Ferreira, Pedro Eduardo
Publicado em: (2012)
por: Ferreira, Pedro Eduardo
Publicado em: (2012)
school Contribution of Sperm Ageing in Epigenetics Signature of Anopheles susceptibility to Plasmodium Malaria Parasite
por: Pereira, Laura Gonçalves
Publicado em: (2022)
por: Pereira, Laura Gonçalves
Publicado em: (2022)
article Translational repression of the cpw-wpc gene family in the malaria parasite Plasmodium
por: Rao, Pavitra N.
Publicado em: (2016)
por: Rao, Pavitra N.
Publicado em: (2016)
article Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria.
por: Costa, , R.M.,
Publicado em: (2013)
por: Costa, , R.M.,
Publicado em: (2013)
school Characterisation of Plasmodium falciparum antigens for the development of serological assay or vaccine candidates for malaria
por: MORENO, Yorleydy Ruiz
Publicado em: (2020)
por: MORENO, Yorleydy Ruiz
Publicado em: (2020)
article Optical spectrophotometry as a promising method for quantification and tage differentiation of plasmodium falciparum parasites
por: Baptista, Vitória
Publicado em: (2023)
por: Baptista, Vitória
Publicado em: (2023)
school Erythropoiesis in malaria infection : the dynamic interaction between inflammation and iron sensors
por: Pêgo, Ana
Publicado em: (2024)
por: Pêgo, Ana
Publicado em: (2024)
article Plasmodium falciparum drug resistance in Angola
por: Fançony, Cláudia
Publicado em: (2016)
por: Fançony, Cláudia
Publicado em: (2016)
school Perfil de anticorpos ANTI-Plasmodium falciparum E citocinas pró-inflamatórias em indivíduos com suspeita clínica de Malária
por: MARTINS, Vanessa Alexandra Agostinho
Publicado em: (2014)
por: MARTINS, Vanessa Alexandra Agostinho
Publicado em: (2014)
school Drepanocitose: etiologia, diagnóstico e abordagens terapêuticas
por: Marques, João Filipe Manuel
Publicado em: (2013)
por: Marques, João Filipe Manuel
Publicado em: (2013)
article Clinical, Laboratorial and Immunological Aspects of Severe Malaria in Children from Guinea-Bissau
por: Domingos, J
Publicado em: (2018)
por: Domingos, J
Publicado em: (2018)
article Malária grave a plasmodium falciparum – a experiência de uma unidade de cuidados intensivos
por: Maia, R
Publicado em: (2017)
por: Maia, R
Publicado em: (2017)
article The impact of antiretroviral therapy on malaria parasite transmission
por: Azevedo, Raquel
Publicado em: (2019)
por: Azevedo, Raquel
Publicado em: (2019)
school Malária por Plasmodium falciparum em Angola: estudos genéticos associados a combinações terapêuticas à base de artemisinina
por: KIACO, Kinanga
Publicado em: (2018)
por: KIACO, Kinanga
Publicado em: (2018)
school Characterization of a new malaria vaccine candidate against Plasmodium vivax using genetically modified rodent Plasmodium parasites
por: Duarte, Miguel Filipe, 1990-
Publicado em: (2014)
por: Duarte, Miguel Filipe, 1990-
Publicado em: (2014)
category CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 Alleles after Amodiaquine-Artesunate treatment
por: Cavaco, Isa
Publicado em: (2013)
por: Cavaco, Isa
Publicado em: (2013)
school Pyruvate kinase deficiency protection against malaria : in vitro evaluation of 2,3-Diphosphoglycerate toxicity and plasmodium falciparum susceptibility
por: Rosa, Ana Margarida Trancoso Gomes, 1988-
Publicado em: (2011)
por: Rosa, Ana Margarida Trancoso Gomes, 1988-
Publicado em: (2011)
groups Deciphering the genetic modifiers of sickle cell anemia in children: the role of CYB5R3 gene
por: Nascimento, Djanira
Publicado em: (2025)
por: Nascimento, Djanira
Publicado em: (2025)
school Plasmodium hepatocyte interactions : implications for protection against malaria
por: LEIRIÃO, Patrícia Rodrigues Saavedra
Publicado em: (2006)
por: LEIRIÃO, Patrícia Rodrigues Saavedra
Publicado em: (2006)
article Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity
por: Carrasco, Marta
Publicado em: (2014)
por: Carrasco, Marta
Publicado em: (2014)
school Defining dihydroartemisinin-piperaquine resistance pathways in the malaria parasite
por: Freitas, Bruno José Ferreira
Publicado em: (2024)
por: Freitas, Bruno José Ferreira
Publicado em: (2024)
school Identification of genes determining mefloquine resistance in Malária parasites
por: BORGES, Sofia Trindade
Publicado em: (2009)
por: BORGES, Sofia Trindade
Publicado em: (2009)
article Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde
por: Da Veiga Leal, Silvania
Publicado em: (2021)
por: Da Veiga Leal, Silvania
Publicado em: (2021)
Registos relacionados
-
groups Haemolysis in sickle cell anaemia: a genotype/phenotype association study
por: Lavinha, João
Publicado em: (2012) -
article Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
por: Herbert, Fabien
Publicado em: (2015) -
article Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status
por: Duarte, J.
Publicado em: (2007) -
article Formas Malignas de Malária por Plasmodium Falciparum
por: Palmeiro Ribeiro, J
Publicado em: (1986) -
article Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak
por: Da Veiga Leal, Silvania
Publicado em: (2021)